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RIPGBM

Name: RIPGBM
Brand: TargetMol
SKU: T16754
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16754Cas No. 355406-76-7

RIPGBM is a selective inducer of apoptosis in glioblastoma multiforme cancer stem cells (EC50: ≤500 nM).

RIPGBM

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Purity: 99.45%

Catalog No. T16754Cas No. 355406-76-7

RIPGBM is a selective inducer of apoptosis in glioblastoma multiforme cancer stem cells (EC50: ≤500 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$32	In Stock	In Stock
5 mg	$52	In Stock	In Stock
10 mg	$89	In Stock	In Stock
25 mg	$197	In Stock	In Stock
50 mg	$353	In Stock	In Stock
100 mg	$589	In Stock	In Stock
200 mg	$753	-	In Stock
1 mL x 10 mM (in DMSO)	$58	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.45%

Appearance:Solid

Color:Orange

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	RIPGBM is a selective inducer of apoptosis in glioblastoma multiforme cancer stem cells (EC50: ≤500 nM).
Targets&IC50	Apoptosis (GBM CSCs):(EC50)≤500 nM
In vitro	RIPGBM causes caspase 1-dependent apoptosis by binding to receptor-interacting protein kinase 2 and acting as a molecular switch. It reduces the formation of a prosurvival RIPK2/ TAK1 complex and increases the formation of a proapoptotic RIPK2/caspase 1 complex [1].

Chemical Properties

Molecular Weight	428.45
Formula	C₂₆H₂₁FN₂O₃
Cas No.	355406-76-7
Smiles	CC(=O)N(CC1=CC=C(F)C=C1)C1=C(NCC2=CC=CC=C2)C(=O)C2=C(C=CC=C2)C1=O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (70.02 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.67 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3340 mL	11.6700 mL	23.3399 mL	116.6997 mL
5 mM	0.4668 mL	2.3340 mL	4.6680 mL	23.3399 mL
10 mM	0.2334 mL	1.1670 mL	2.3340 mL	11.6700 mL
20 mM	0.1167 mL	0.5835 mL	1.1670 mL	5.8350 mL
50 mM	0.0467 mL	0.2334 mL	0.4668 mL	2.3340 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc