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Hellebrigenin, as a selective inhibitor of MAPK signaling pathways (ERK, p38, JNK) and XIAP, effectively suppresses Akt expression and phosphorylation. This compound activates endogenous apoptosis pathways (including mitochondrial membrane potential disruption, Caspase family activation, and PARP cleavage) while modulating apoptosis-related protein expression. Hellebrigenin also induces DNA double-strand breaks to activate the ATM pathway, inhibiting tumor cell proliferation and clonogenesis, primarily applied in research of oral squamous cell carcinoma and liver cancer.

| Pack Size | Price | Availability | Quantity | 
|---|---|---|---|
| 1 mg | $107 | In Stock | |
| 5 mg | $263 | In Stock | |
| 10 mg | $392 | In Stock | |
| 25 mg | $645 | In Stock | 
| Description | Hellebrigenin, as a selective inhibitor of MAPK signaling pathways (ERK, p38, JNK) and XIAP, effectively suppresses Akt expression and phosphorylation. This compound activates endogenous apoptosis pathways (including mitochondrial membrane potential disruption, Caspase family activation, and PARP cleavage) while modulating apoptosis-related protein expression. Hellebrigenin also induces DNA double-strand breaks to activate the ATM pathway, inhibiting tumor cell proliferation and clonogenesis, primarily applied in research of oral squamous cell carcinoma and liver cancer. | 
| In vitro | Methods: Oral cancer SCC-1/47 cells and liver cancer HepG2 cells were treated with Hellebrigenin (2-8 nM, 24-72 h), and cell viability was detected by MTT assay. Results: Hellebrigenin inhibited the cell viability of oral cancer SCC-1/47 cells and liver cancer HepG2 cells in a dose- and time-dependent manner. Methods: Oral cancer SCC-1/47 cells were treated with Hellebrigenin (2-8 nM, 24 h), and the expression of related apoptosis proteins was detected by WB. Results: Hellebrigenin induced apoptosis in oral cancer SCC-1/47 cells and activated Caspase-3/8/9 and PARP cleavage, accompanied by upregulation of Bax/Bak and downregulation of Bcl-2/Bcl-xL, Cyclin A2/B1, and CDK4/6. [1] | 
| In vivo | Methods: Hellebrigenin (6 mg/kg, intraperitoneal injection, three times a week for 4 weeks) was used to treat oral cancer SCC-1 cell xenograft model mice to study its effects on tumor growth and mouse body weight. Methods: Hellebrigenin significantly inhibited tumor growth in the oral cancer SCC-1 cell xenograft model of mice without affecting mouse body weight. [1] | 
| Molecular Weight | 416.51 | 
| Formula | C24H32O6 | 
| Cas No. | 465-90-7 | 
| Smiles | C(=O)[C@@]12[C@@]3([C@]([C@]4(O)[C@](C)(CC3)[C@H](CC4)C=5C=CC(=O)OC5)(CC[C@]1(O)C[C@@H](O)CC2)[H])[H] | 
| Relative Density. | 1.419g/cm3 | 
| Color | White | 
| Appearance | Solid | 
| Storage | keep away from moisture,keep away from direct sunlight,The compound is unstable in solution. Please use soon | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | 
 For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL .
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL .  A total of 10 animals were administered, and the formula you used is 5%
 A total of 10 animals were administered, and the formula you used is 5%  DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。 (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
 (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first. main solution, add 300 μLPEG300
 main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O
 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
 mix well and clarify
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