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Ceftizoxime
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Catalog No. T4501Cas No. 68401-81-0
Alias Epocelin
Ceftizoxime (Epocelin) is a cephalosporin-based, potent antibacterial agent which can be administered intravenously or by suppository. It is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms.
Ceftizoxime
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Purity: 99.91%
Catalog No. T4501Alias EpocelinCas No. 68401-81-0
Ceftizoxime (Epocelin) is a cephalosporin-based, potent antibacterial agent which can be administered intravenously or by suppository. It is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $33 | In Stock | In Stock | |
| 50 mg | $44 | In Stock | In Stock | |
| 100 mg | $70 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $29 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.91%
Appearance:Solid
Color:White
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Product Introduction
Ceftizoxime AI Summary
Ceftizoxime demonstrates a range of bioactivities and pharmacokinetic properties. It acts as a potent antimicrobial agent with in vitro minimum inhibitory concentrations (MIC) values as low as 0.025 µg/mL against Escherichia coli, Klebsiella pneumonia, and Proteus mirabilis. It also shows activity against other bacteria like Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, and Serratia marcescens with MIC values from 6.25 to 50.0 µg/mL. Additionally, it exhibits activity against various strains of Staphylococcus, including oxacillin-resistant and methicillin-resistant strains, with MIC values ranging from 0.12 to 800.0 µg/mL.
Pharmacokinetically, Ceftizoxime has a plasma half-life of approximately 0.25 hours in rats, 0.7333 hours in monkeys, and 1.6 hours in humans after intravenous administration. It shows a total body clearance (CL) of 2.1 mL/min/kg and a renal clearance (CL_renal) of 1.68 mL/min/kg in humans. The compound has good pharmacokinetic properties with a half-life ranging from 0.22 to 0.23 hours, and a high fAUC/MIC ratio of 1000.0, indicating its potential as an effective antimicrobial agent.
Ceftizoxime also shows significant liver enzyme activity, increasing levels of alkaline phosphatase, SGOT, SGPT, and LDH, although it has no observed bioactivities related to drug-induced liver injury according to the Drug Induced Liver Injury Prediction System (DILIps). The compound is a substrate for the human MRP4 transporter, with a Km value of 18000.0 nM, and exhibits inhibitory activity against the human HDAC6 enzyme, indicating potential as an HDAC6 inhibitor. It also exhibits bioactivity as a binding agent to multiple receptors and shows various activities including agonist and antagonist actions with high AC50 values above 17000.0 nM..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Ceftizoxime (Epocelin) is a cephalosporin-based, potent antibacterial agent which can be administered intravenously or by suppository. It is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms. |
| Synonyms | Epocelin |
| Molecular Weight | 383.40 |
| Formula | C13H13N5O5S2 |
| Cas No. | 68401-81-0 |
| Smiles | O=C1N2[C@@]([C@@H]1NC(/C(=N\OC)/C3=CSC(N)=N3)=O)(SCC=C2C(O)=O)[H] |
| Relative Density. | 1.89 g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 25.00 mg/mL (65.21 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.00 mg/mL (5.22 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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