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HEPPS

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Catalog No. T20821Cas No. 16052-06-5

HEPPS exhibits inhibitory activity against the amyloid-beta precursor protein, reducing Aβ aggregation burden and improving neuronal autophagy flux, thereby alleviating neuronal apoptosis and traumatic brain injury (TBI) in mice. It can be used for research into Alzheimer's disease and neurological disorders.

HEPPS

HEPPS

🥰Excellent
Catalog No. T20821Cas No. 16052-06-5
HEPPS exhibits inhibitory activity against the amyloid-beta precursor protein, reducing Aβ aggregation burden and improving neuronal autophagy flux, thereby alleviating neuronal apoptosis and traumatic brain injury (TBI) in mice. It can be used for research into Alzheimer's disease and neurological disorders.
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50 g$31In Stock
100 g$45In Stock
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Product Introduction

Bioactivity
Description
HEPPS exhibits inhibitory activity against the amyloid-beta precursor protein, reducing Aβ aggregation burden and improving neuronal autophagy flux, thereby alleviating neuronal apoptosis and traumatic brain injury (TBI) in mice. It can be used for research into Alzheimer's disease and neurological disorders.
In vivo
Methods:
A mouse model of traumatic brain injury (TBI) was established using controlled cortical impact (CCI). HEPPS was administered orally at a dose of 120 mg/kg immediately after injury and then once daily for 3 or 7 days. Aβ accumulation, autophagy, apoptosis, and neurological function were evaluated through histological and molecular analyses. A chloroquine-treated group was included to assess whether the effects of HEPPS were mediated through autophagy.
Results:
HEPPS significantly reduced Aβ accumulation and axonal injury in the brain after TBI, improved synaptic function and autophagic flux, decreased neuronal apoptosis, prevented brain tissue loss, and enhanced motor and cognitive functions. These protective effects were partially reversed by chloroquine treatment, suggesting that the neuroprotective effect of HEPPS is associated with enhanced autophagy [1].
Chemical Properties
Molecular Weight252.33
FormulaC9H20N2O4S
Cas No.16052-06-5
SmilesO=S(=O)(O)CCCN1CCN(CCO)CC1
Relative Density.1.285g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
H2O: 200 mg/mL (792.61 mM), Sonication is recommended.
DMSO: 1 mg/mL (3.96 mM), Sonication is recommended.
Solution Preparation Table
DMSO/H2O
1mg5mg10mg50mg
1 mM3.9631 mL19.8153 mL39.6306 mL198.1532 mL
H2O
1mg5mg10mg50mg
5 mM0.7926 mL3.9631 mL7.9261 mL39.6306 mL
10 mM0.3963 mL1.9815 mL3.9631 mL19.8153 mL
20 mM0.1982 mL0.9908 mL1.9815 mL9.9077 mL
50 mM0.0793 mL0.3963 mL0.7926 mL3.9631 mL
100 mM0.0396 mL0.1982 mL0.3963 mL1.9815 mL

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