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HEPPS
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Catalog No. T20821Cas No. 16052-06-5
HEPPS exhibits inhibitory activity against the amyloid-beta precursor protein, reducing Aβ aggregation burden and improving neuronal autophagy flux, thereby alleviating neuronal apoptosis and traumatic brain injury (TBI) in mice. It can be used for research into Alzheimer's disease and neurological disorders.
HEPPS
Copy Product Info😃Good
Catalog No. T20821Cas No. 16052-06-5
HEPPS exhibits inhibitory activity against the amyloid-beta precursor protein, reducing Aβ aggregation burden and improving neuronal autophagy flux, thereby alleviating neuronal apoptosis and traumatic brain injury (TBI) in mice. It can be used for research into Alzheimer's disease and neurological disorders.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 g | $31 | - | In Stock | |
| 100 g | $45 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | HEPPS exhibits inhibitory activity against the amyloid-beta precursor protein, reducing Aβ aggregation burden and improving neuronal autophagy flux, thereby alleviating neuronal apoptosis and traumatic brain injury (TBI) in mice. It can be used for research into Alzheimer's disease and neurological disorders. |
| In vivo | Methods: A mouse model of traumatic brain injury (TBI) was established using controlled cortical impact (CCI). HEPPS was administered orally at a dose of 120 mg/kg immediately after injury and then once daily for 3 or 7 days. Aβ accumulation, autophagy, apoptosis, and neurological function were evaluated through histological and molecular analyses. A chloroquine-treated group was included to assess whether the effects of HEPPS were mediated through autophagy. Results: HEPPS significantly reduced Aβ accumulation and axonal injury in the brain after TBI, improved synaptic function and autophagic flux, decreased neuronal apoptosis, prevented brain tissue loss, and enhanced motor and cognitive functions. These protective effects were partially reversed by chloroquine treatment, suggesting that the neuroprotective effect of HEPPS is associated with enhanced autophagy [1]. |
| Molecular Weight | 252.33 |
| Formula | C9H20N2O4S |
| Cas No. | 16052-06-5 |
| Smiles | O=S(=O)(O)CCCN1CCN(CCO)CC1 |
| Relative Density. | 1.285g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 200 mg/mL (792.61 mM), Sonication is recommended. DMSO: 1 mg/mL (3.96 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
DMSO/H2O
H2O
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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