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ABTL-0812

Name: ABTL-0812
Brand: TargetMol
SKU: T13430
Rating: 4.5 (1 reviews)

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Catalog No. T13430Cas No. 57818-44-7

Alias α-Hydroxylinoleic acid, ABTL0812, ABTL 0812

ABTL-0812 (α-Hydroxylinoleic acid) is a first-in-class small-molecule compound that induces endoplasmic reticulum stress–mediated autophagy, leading to cancer cell death, ABTL-0812 is extensively applied in oncology research to investigate ER stress signaling, autophagic cell death pathways, and novel anticancer mechanisms with translational therapeutic potential.

ABTL-0812

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Catalog No. T13430Alias α-Hydroxylinoleic acid, ABTL0812, ABTL 0812Cas No. 57818-44-7

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,200	6-8 weeks	6-8 weeks
50 mg	$1,570	6-8 weeks	6-8 weeks
100 mg	$2,500	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	ABTL-0812 (α-Hydroxylinoleic acid) is a first-in-class small-molecule compound that induces endoplasmic reticulum stress–mediated autophagy, leading to cancer cell death, ABTL-0812 is extensively applied in oncology research to investigate ER stress signaling, autophagic cell death pathways, and novel anticancer mechanisms with translational therapeutic potential.
In vitro	In squamous Non-Small Cell Lung Cancer (NSCLC) H157 cells, treatment with ABTL-0812 (10-100 μM) for 48 hours inhibited cell viability by increasing intracellular dihydroceramide levels and triggering autophagy [1].
In vivo	In athymic nude mice bearing human pancreatic (MiaPaca2) and lung (A549) cancer xenografts, oral administration of ABTL-0812 (120 mg/kg, 5 times per week) for 33 days induced ER stress within tumor tissues. This was characterized by the upregulated expression of ER stress markers ATF4 and HSPA5 (BiP/GRP78) in the treated group compared to controls [1].
Synonyms	α-Hydroxylinoleic acid, ABTL0812, ABTL 0812

Chemical Properties

Molecular Weight	296.44
Formula	C₁₈H₃₂O₃
Cas No.	57818-44-7
Smiles	C(CCC(C(O)=O)O)CCC/C=C\C/C=C\CCCCC
Relative Density.	0.970 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 72 mg/mL (242.88 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3734 mL	16.8668 mL	33.7336 mL	168.6682 mL
5 mM	0.6747 mL	3.3734 mL	6.7467 mL	33.7336 mL
10 mM	0.3373 mL	1.6867 mL	3.3734 mL	16.8668 mL
20 mM	0.1687 mL	0.8433 mL	1.6867 mL	8.4334 mL
50 mM	0.0675 mL	0.3373 mL	0.6747 mL	3.3734 mL
100 mM	0.0337 mL	0.1687 mL	0.3373 mL	1.6867 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

alpha-Hydroxylinoleic acida-Hydroxylinoleic acidABTL-0812