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ABTL-0812

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Catalog No. T13430Cas No. 57818-44-7
Alias α-Hydroxylinoleic acid, ABTL0812, ABTL 0812

ABTL-0812 (α-Hydroxylinoleic acid) is a first-in-class small-molecule compound that induces endoplasmic reticulum stress–mediated autophagy, leading to cancer cell death, ABTL-0812 is extensively applied in oncology research to investigate ER stress signaling, autophagic cell death pathways, and novel anticancer mechanisms with translational therapeutic potential.

ABTL-0812

ABTL-0812

😃Good
Catalog No. T13430Alias α-Hydroxylinoleic acid, ABTL0812, ABTL 0812Cas No. 57818-44-7
ABTL-0812 (α-Hydroxylinoleic acid) is a first-in-class small-molecule compound that induces endoplasmic reticulum stress–mediated autophagy, leading to cancer cell death, ABTL-0812 is extensively applied in oncology research to investigate ER stress signaling, autophagic cell death pathways, and novel anticancer mechanisms with translational therapeutic potential.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$1,2006-8 weeks6-8 weeks
50 mg$1,5706-8 weeks6-8 weeks
100 mg$2,5006-8 weeks6-8 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
ABTL-0812 (α-Hydroxylinoleic acid) is a first-in-class small-molecule compound that induces endoplasmic reticulum stress–mediated autophagy, leading to cancer cell death, ABTL-0812 is extensively applied in oncology research to investigate ER stress signaling, autophagic cell death pathways, and novel anticancer mechanisms with translational therapeutic potential.
In vitro
In squamous Non-Small Cell Lung Cancer (NSCLC) H157 cells, treatment with ABTL-0812 (10-100 μM) for 48 hours inhibited cell viability by increasing intracellular dihydroceramide levels and triggering autophagy [1].
In vivo
In athymic nude mice bearing human pancreatic (MiaPaca2) and lung (A549) cancer xenografts, oral administration of ABTL-0812 (120 mg/kg, 5 times per week) for 33 days induced ER stress within tumor tissues. This was characterized by the upregulated expression of ER stress markers ATF4 and HSPA5 (BiP/GRP78) in the treated group compared to controls [1].
Synonymsα-Hydroxylinoleic acid, ABTL0812, ABTL 0812
Chemical Properties
Molecular Weight296.44
FormulaC18H32O3
Cas No.57818-44-7
SmilesC(CCC(C(O)=O)O)CCC/C=C\C/C=C\CCCCC
Relative Density.0.970 g/cm3 (Predicted)
Storage & Solubility Information
StorageIn solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 72 mg/mL (242.88 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.3734 mL16.8668 mL33.7336 mL168.6682 mL
5 mM0.6747 mL3.3734 mL6.7467 mL33.7336 mL
10 mM0.3373 mL1.6867 mL3.3734 mL16.8668 mL
20 mM0.1687 mL0.8433 mL1.6867 mL8.4334 mL
50 mM0.0675 mL0.3373 mL0.6747 mL3.3734 mL
100 mM0.0337 mL0.1687 mL0.3373 mL1.6867 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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Keywords

alpha-Hydroxylinoleic acida-Hydroxylinoleic acidABTL-0812
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