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PKM2-IN-6
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Catalog No. T87217Cas No. 771467-00-6
PKM2-IN-6 (compound 7d) is an orally active PKM2 inhibitor (IC50=23 nM) capable of inducing apoptosis and G2 cell cycle arrest. It reduces PKM1 and PKM2 expression at the mRNA level, exhibits antitumour activity, and is suitable for investigating triple-negative breast cancer (TNBC).
PKM2-IN-6
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Purity: 99.83%
Catalog No. T87217Cas No. 771467-00-6
PKM2-IN-6 (compound 7d) is an orally active PKM2 inhibitor (IC50=23 nM) capable of inducing apoptosis and G2 cell cycle arrest. It reduces PKM1 and PKM2 expression at the mRNA level, exhibits antitumour activity, and is suitable for investigating triple-negative breast cancer (TNBC).
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $88 | - | In Stock | |
| 5 mg | $218 | - | In Stock | |
| 10 mg | $328 | - | In Stock | |
| 25 mg | $553 | - | In Stock | |
| 50 mg | $796 | - | In Stock | |
| 100 mg | $1,090 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.83%
Appearance:Solid
Color:Yellow to Brown
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | PKM2-IN-6 (compound 7d) is an orally active PKM2 inhibitor (IC50=23 nM) capable of inducing apoptosis and G2 cell cycle arrest. It reduces PKM1 and PKM2 expression at the mRNA level, exhibits antitumour activity, and is suitable for investigating triple-negative breast cancer (TNBC). |
| In vitro | PKM2-IN-6 (compound 7d) (0-100 μM) exhibited cytotoxicity against COLO-205, A-549, and MCF-7 cells after 48 hours of treatment, with IC₅₀ values of 18.33 μM, 47.00 μM, and 19.80 μM, respectively [1]. PKM2-IN-6 (14.38 μM) induced apoptosis and caused cell cycle arrest at the G2 phase after 48 hours of treatment [1]. PKM2-IN-6 (14.38 μM) downregulated the expression of PKM1 and PKM2 at the mRNA level after 24 hours of treatment [1]. |
| In vivo | PKM2-IN-6 (25 and 50 mg/kg, orally administered once daily for three weeks) significantly reduced tumor volume and weight in female CD-1 nude mice (6-8 weeks old) inoculated with 4T1-Red-FLuc cells [1]. |
| Molecular Weight | 322.38 |
| Formula | C17H14N4OS |
| Cas No. | 771467-00-6 |
| Smiles | N(C1=NC(C=2N3C(=NC2)C=CC=C3)=CS1)C4=C(OC)C=CC=C4 |
| Storage | keep away from moisture,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (310.19 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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