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Anti-PAX8 Antibody (7Q264)
😃Good
Catalog No. TMAC-03081
Alias paired box 8
Anti-PAX8 Antibody (7Q264) is a Rabbit antibody targeting PAX8. Anti-PAX8 Antibody (7Q264) can be used in WB,ICC/IF,IHC.
Anti-PAX8 Antibody (7Q264)
Anti-PAX8 Antibody (7Q264)
😃Good
Catalog No. TMAC-03081Alias paired box 8
Anti-PAX8 Antibody (7Q264) is a Rabbit antibody targeting PAX8. Anti-PAX8 Antibody (7Q264) can be used in WB,ICC/IF,IHC.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $297 | 7-10 days | |
| 100 μL | $498 | 7-10 days |
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Product Introduction
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Antigen Details
Chemical Properties
| Description | Anti-PAX8 Antibody (7Q264) is a Rabbit antibody targeting PAX8. Anti-PAX8 Antibody (7Q264) can be used in WB,ICC/IF,IHC. |
| Synonyms | paired box 8 |
| Ig Type | IgG |
| Clone | 7Q264 |
| Reactivity | Human |
| Verified Activity | 1. Western blot analysis of PAX8 on SKOV-3 cells lysates using anti-PAX8 antibody at 1/1,000 dilution. 2. Immunohistochemical analysis of paraffin-embedded human thyroid tissue using anti-PAX8 antibody. Counter stained with hematoxylin. 3. Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissue using anti-PAX8 antibody. Counter stained with hematoxylin. 4. ICC staining PAX8 in SKOV-3 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. |
| Application | |
| Recommended Dose | WB: 1:1000-2000; IHC: 1:50-200; ICC/IF: 1:50-200 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | The Pax family encodes transcription factors that function during embryogenesis and regulate the temporal and position-dependent differentiation of cells. Pax-8 is expressed in the developing and adult thyroid, the developing secretory system and at lower levels, in the adult kidney. Pax-8 complexes with TTF-1 and TTF-2 to induce thyroid follicular cell differentiation and thyroid hormone biosynthesis by regulating the expression of sodium iodide symporter (NIS), thyroid peroxidase (TPO), thyroglobulin (TG) and the thyrotropin receptor (TSHR). Treatment of FRTL-5 cells with TGFβ1 decreases Pax-8 mRNA levels and Pax-8 DNA binding activity, which suppresses the expression of TG and the formation of thyrocytes. Patients who have autosomal dominant mutations of the Pax-8 gene develop thyroid dysgenesis. The Pax-8 gene produces six isoforms, A to F, that are generated by alternative splicing and differ in their carboxy-terminal regions. The Pax-8 isoforms display different DNA binding capacities and are thought to be functionally distinct. The gene which encodes Pax-8 maps to human chromosome 2q12-q14. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein |
| Uniprot ID |
| Molecular Weight | Theoretical: 48 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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