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Anti-OST beta Polyclonal Antibody
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Catalog No. TMAB-01292
Alias Ostbeta, OSTB, Ost beta, Organic solute transporter subunit beta, organic solute transporter beta(Ostbeta)
Anti-OST beta Polyclonal Antibody is a Rabbit antibody targeting OST beta. Anti-OST beta Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF,ELISA.
Anti-OST beta Polyclonal Antibody
Anti-OST beta Polyclonal Antibody
😃Good
Catalog No. TMAB-01292Alias Ostbeta, OSTB, Ost beta, Organic solute transporter subunit beta, organic solute transporter beta(Ostbeta)
Anti-OST beta Polyclonal Antibody is a Rabbit antibody targeting OST beta. Anti-OST beta Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF,ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $220 | 7-10 days | |
| 100 μL | $374 | 7-10 days | |
| 200 μL | $527 | 7-10 days |
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-OST beta Polyclonal Antibody is a Rabbit antibody targeting OST beta. Anti-OST beta Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF,ELISA. |
| Synonyms | Ostbeta, OSTB, Ost beta, Organic solute transporter subunit beta, organic solute transporter beta(Ostbeta) |
| Ig Type | IgG |
| Reactivity | (predicted:Human,Mouse,Rat) |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500; ELISA: 1:5000-10000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cell membrane. Mainly restricted to the lateral and basal membranes of ileal enterocytes. |
| Tissue Specificity | Widely expressed with a high expression in ileum. Expressed in testis, colon, liver, small intestine, kidney, ovary and adrenal gland; and at low levels in heart, lung, brain, pituitary, thyroid gland, uterus, prostate, mammary gland and fat. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | The heteromeric transporter OST Alpha/OST Beta facilitates the transport of bile and other steroid solutes across the basolateral epithelial cell membrane of intestine, liver, testis, kidney and adrenal gland. OST Alpha/OST Beta expression is induced by bile acids through ligand-dependent transactivation of their genes by FXR (Farnesoid X-activated receptor). This genetic regulation suggests that in response to changes in intracellular bile acid levels, bile acids adjust the rate of their own efflux from enterocytes. OST Beta is a 128 amino acid single-pass transmembrane protein that requires OST Alpha to localize to the plasma membrane. Coexpression of OST Alpha and OST Beta is also required to convert the OST Alpha subunit to a mature glycosylated endoglycosidase H-resistant form, suggesting that co-expression facilitates trafficking of OST Alpha through the golgi apparatus. Though widely expressed, OST Beta is present at highest levels in ileum. |
| Immunogen | KLH conjugated synthetic peptide: human OST-beta |
| Antigen Species | Human |
| Gene Name | SLC51B |
| Gene ID | |
| Protein Name | Organic solute transporter subunit beta |
| Uniprot ID | |
| Biology Area | Channels |
| Function | Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids. Modulates SLC51A glycosylation, membrane trafficking and stability activities. |
| Molecular Weight | Theoretical: 14 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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