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Anti-OST beta Polyclonal Antibody is a Rabbit antibody targeting OST beta. Anti-OST beta Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF,ELISA.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 μL | $220 | 7-10 days | |
100 μL | $374 | 7-10 days | |
200 μL | $527 | 7-10 days |
Description | Anti-OST beta Polyclonal Antibody is a Rabbit antibody targeting OST beta. Anti-OST beta Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF,ELISA. |
Alias | Ostbeta, OSTB, Ost beta, Organic solute transporter subunit beta, organic solute transporter beta(Ostbeta) |
Ig Type | IgG |
Reactivity | (predicted:Human,Mouse,Rat) |
Application | IHC-P,IHC-Fr,IF,ELISA |
Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500; ELISA: 1:5000-10000 |
Antibody Type | Polyclonal |
Host Species | Rabbit |
Subcellular Localization | Cell membrane. Mainly restricted to the lateral and basal membranes of ileal enterocytes. |
Construction | Hybridoma Polyclonal Antibody |
Purification | Protein A purified |
Appearance | Liquid |
Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
Research Background | The heteromeric transporter OST Alpha/OST Beta facilitates the transport of bile and other steroid solutes across the basolateral epithelial cell membrane of intestine, liver, testis, kidney and adrenal gland. OST Alpha/OST Beta expression is induced by bile acids through ligand-dependent transactivation of their genes by FXR (Farnesoid X-activated receptor). This genetic regulation suggests that in response to changes in intracellular bile acid levels, bile acids adjust the rate of their own efflux from enterocytes. OST Beta is a 128 amino acid single-pass transmembrane protein that requires OST Alpha to localize to the plasma membrane. Coexpression of OST Alpha and OST Beta is also required to convert the OST Alpha subunit to a mature glycosylated endoglycosidase H-resistant form, suggesting that co-expression facilitates trafficking of OST Alpha through the golgi apparatus. Though widely expressed, OST Beta is present at highest levels in ileum. |
Immunogen | KLH conjugated synthetic peptide: human OST-beta |
Antigen Species | Human |
Gene ID | |
Uniprot ID | |
Biology Area | Channels |
Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
Transport | Shipping with blue ice. |
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