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Anti-TRPM8 Antibody (1W708)
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Catalog No. TMAH-01215
Alias Trp-p8, TRPP8, TRPM 8, Transient receptor potential p8, Transient receptor potential cation channel subfamily M member 8, LTrpC-6, LTrpC6, LTRPC6, Long transient receptor potential channel 6
Anti-TRPM8 Antibody (1W708) is an antibody targeting TRPM8. Anti-TRPM8 Antibody (1W708) can be used in ELISA, IHC.
Anti-TRPM8 Antibody (1W708)
Anti-TRPM8 Antibody (1W708)
😃Good
Catalog No. TMAH-01215Alias Trp-p8, TRPP8, TRPM 8, Transient receptor potential p8, Transient receptor potential cation channel subfamily M member 8, LTrpC-6, LTrpC6, LTRPC6, Long transient receptor potential channel 6
Anti-TRPM8 Antibody (1W708) is an antibody targeting TRPM8. Anti-TRPM8 Antibody (1W708) can be used in ELISA, IHC.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $207 | 7-10 days | |
| 100 μL | $348 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Recombinant Rabbit Monoclonal Application: ELISA, IHC Reactivity: Human |
| Alias | Trp-p8, TRPP8, TRPM 8, Transient receptor potential p8, Transient receptor potential cation channel subfamily M member 8, LTrpC-6, LTrpC6, LTRPC6, Long transient receptor potential channel 6 |
| Ig Type | Rabbit IgG |
| Clone | 1W708 |
| Reactivity | Human |
| Verified Activity | IHC image of TMAH-01215 diluted at 1:100 and staining in paraffin-embedded human prostate cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB. |
| Application | ELISA, IHC |
| Recommended Dose | IHC:1:50-1:200. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Cell membrane; Multi-pass membrane protein. Membrane raft. Endoplasmic reticulum membrane. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonist menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. In prostate cancer cells, shows strong inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is characterized by outward rectification and poor cationic selectivity. Plays a role in prostate cancer cell migration. Isoform 2 and isoform 3 negatively regulate menthol- and cold-induced channel activity by stabilizing the closed state of the channel. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human TRPM8 |
| Antigen Species | Human |
| Gene ID | 79054 |
| Uniprot ID | |
| Biology Area | Neuroscience, Cancer, Metabolism, Signal transduction |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
Sci Citations
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