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ML-60218

Catalog No. T40661 CAS 577784-91-9

ML-60218 is an inhibitor of broad-spectrum RNA pol III with IC50s of 32 and 27 μM for Saccharomyces cerevisiae and human. ML-60218 disrupts already assembled viroplasms and hampers the formation of new viroplasms.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

ML-60218, CAS 577784-91-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 51.00
2 mg	In stock	$ 74.00
5 mg	In stock	$ 122.00
10 mg	In stock	$ 197.00
25 mg	In stock	$ 455.00
50 mg	In stock	$ 672.00
100 mg	In stock	$ 956.00
1 mL * 10 mM (in DMSO)	In stock	$ 133.00

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Purity: 98.1%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vitro

ML-60218 reverses SAHA-stimulated tRNA expression in PANC-1 and BxPC-3 cells. ML-60218 enhances the ability of HDAC inhibitors to induce apoptosis and cell cycle arrest. The combination of SAHA and ML-60218 produces enhanced suppression of proliferation in human pancreatic adenocarcinoma by impairing cell cycle progression and inducing apoptosis[1]. ML-60218 interferes with the formation of higher-order structures of VP6, the protein forming the DLP outer layer, without compromising its ability to trimerize. ML-60218-mediated (10 μM ) viroplasm disruption causes NSP5 dephosphorylation. Electron microscopy of ML-60218-treated DLPs shows dose-dependent structural damage[2].

Molecular Weight	452.38
Formula	C19H15Cl2N3O2S2
CAS No.	577784-91-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

DMSO: 95 mg/mL (210.00 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Yee NS, et al. Targeting developmental regulators of zebrafish exocrine pancreas as a therapeutic approach in human pancreatic cancer. Biol Open. 2012;1(4):295-307. 2. Eichwald C, et al. Identification of a Small Molecule That Compromises the Structural Integrity of Viroplasms and Rotavirus Double-Layered Particles. J Virol. 2018;92(3):e01943-17. Published 2018 Jan 17. 3. Wu L, et al. Novel small-molecule inhibitors of RNA polymerase III. Eukaryot Cell. 2003;2(2):256-264.

Citations

1. Wei W, Zhang S, Han H, et al.NAT10-mediated ac4C tRNA modification promotes EGFR mRNA translation and gefitinib resistance in cancer.Cell Reports.2023, 42(7).

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Compound Library Bioactive Compound Library Bioactive Compounds Library Max DNA Damage & Repair Compound Library

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Related compounds with same targets

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

ML-60218 577784-91-9 Cell Cycle/Checkpoint DNA Damage/DNA Repair DNA/RNA Synthesis transcription inhibit broad-spectrum Inhibitor viroplasms ML 60218 yeast ML60218 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.