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ML-60218

Name: ML-60218
Brand: TargetMol
SKU: T40661
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T40661Cas No. 577784-91-9

ML-60218 is an inhibitor of broad-spectrum RNA pol III with IC50s of 32 and 27 μM for Saccharomyces cerevisiae and human. ML-60218 disrupts already assembled viroplasms and hampers the formation of new viroplasms.

ML-60218

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Purity: 98.1%

Catalog No. T40661Cas No. 577784-91-9

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$48	In Stock	In Stock
5 mg	$116	In Stock	In Stock
10 mg	$187	In Stock	In Stock
25 mg	$411	In Stock	In Stock
50 mg	$638	In Stock	In Stock
100 mg	$908	-	In Stock
200 mg	$1,220	-	In Stock
1 mL x 10 mM (in DMSO)	$126	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:98.1%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description

In vitro

ML-60218 reverses SAHA-stimulated tRNA expression in PANC-1 and BxPC-3 cells. ML-60218 enhances the ability of HDAC inhibitors to induce apoptosis and cell cycle arrest. The combination of SAHA and ML-60218 produces enhanced suppression of proliferation in human pancreatic adenocarcinoma by impairing cell cycle progression and inducing apoptosis[1]. ML-60218 interferes with the formation of higher-order structures of VP6, the protein forming the DLP outer layer, without compromising its ability to trimerize. ML-60218-mediated (10 μM ) viroplasm disruption causes NSP5 dephosphorylation. Electron microscopy of ML-60218-treated DLPs shows dose-dependent structural damage[2].

Chemical Properties

Molecular Weight	452.38
Formula	C₁₉H₁₅Cl₂N₃O₂S₂
Cas No.	577784-91-9
Smiles	Cc1c(sc2ccc(Cl)cc12)-c1cc(NS(=O)(=O)c2ccccc2Cl)n(C)n1
Relative Density.	no data available

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 252.5 mg/mL (558.16 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.29 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2105 mL	11.0527 mL	22.1053 mL	110.5265 mL
5 mM	0.4421 mL	2.2105 mL	4.4211 mL	22.1053 mL
10 mM	0.2211 mL	1.1053 mL	2.2105 mL	11.0527 mL
20 mM	0.1105 mL	0.5526 mL	1.1053 mL	5.5263 mL
50 mM	0.0442 mL	0.2211 mL	0.4421 mL	2.2105 mL
100 mM	0.0221 mL	0.1105 mL	0.2211 mL	1.1053 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc