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FAPy-adenine

Name: FAPy-adenine
Brand: TargetMol
SKU: T19320
Price: 89 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T19320Cas No. 5122-36-1

Alias 4,6-diamino-5-n-formamidopyrimidine

FAPy-adenine (4,6-diamino-5-N-formamidopyrimidine) is an oxidised DNA base, and its levels in the brains of Alzheimer's disease patients show an upward trend.

FAPy-adenine

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Purity: 99.95%

Catalog No. T19320Alias 4,6-diamino-5-n-formamidopyrimidineCas No. 5122-36-1

FAPy-adenine (4,6-diamino-5-N-formamidopyrimidine) is an oxidised DNA base, and its levels in the brains of Alzheimer's disease patients show an upward trend.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$33	-	In Stock
5 mg	Preferential	In Stock	In Stock
10 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$89	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.95%

Appearance:Solid

Color:Yellow

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COA

Product Introduction

Bioactivity

Description	FAPy-adenine (4,6-diamino-5-N-formamidopyrimidine) is an oxidised DNA base, and its levels in the brains of Alzheimer's disease patients show an upward trend.
In vitro	In the absence of the external field the FAPy-adenine is able to form pairs with all four canonical nucleic acid bases. In contrast, in the presence of the external field the mispairing abilities of FAPy-adenine become insignificant since the most stable dimers are formed with thymine.[1]
In vivo	There is an increased trend in the levels of FAPy-adenine in the AD brain. The nuclear DNA damage by oxygen-derived radicals is increased in Alzheimer's disease and support the concept that the brain is under increased oxidative stress in Alzheimer's disease.[1]
Synonyms	4,6-diamino-5-n-formamidopyrimidine

Chemical Properties

Molecular Weight	153.14
Formula	C₅H₇N₅O
Cas No.	5122-36-1
Smiles	O=CNC=1C(=NC=NC1N)N
Relative Density.	1.575 g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 15 mg/mL (97.95 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (6.53 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.5300 mL	32.6499 mL	65.2997 mL	326.4986 mL
5 mM	1.3060 mL	6.5300 mL	13.0599 mL	65.2997 mL
10 mM	0.6530 mL	3.2650 mL	6.5300 mL	32.6499 mL
20 mM	0.3265 mL	1.6325 mL	3.2650 mL	16.3249 mL
50 mM	0.1306 mL	0.6530 mL	1.3060 mL	6.5300 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc