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FAPy-adenine

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Catalog No. T19320Cas No. 5122-36-1
Alias 4,6-diamino-5-n-formamidopyrimidine

FAPy-adenine (4,6-diamino-5-N-formamidopyrimidine) is an oxidised DNA base, and its levels in the brains of Alzheimer's disease patients show an upward trend.

FAPy-adenine

FAPy-adenine

🥰Excellent
Purity: 99.95%
Catalog No. T19320Alias 4,6-diamino-5-n-formamidopyrimidineCas No. 5122-36-1
FAPy-adenine (4,6-diamino-5-N-formamidopyrimidine) is an oxidised DNA base, and its levels in the brains of Alzheimer's disease patients show an upward trend.
Pack SizePriceAvailabilityQuantity
5 mg$87In Stock
10 mg$140In Stock
1 mL x 10 mM (in DMSO)$154In Stock
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Purity:99.95%
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Product Introduction

Bioactivity
Description
FAPy-adenine (4,6-diamino-5-N-formamidopyrimidine) is an oxidised DNA base, and its levels in the brains of Alzheimer's disease patients show an upward trend.
In vitro
In the absence of the external field the FAPy-adenine is able to form pairs with all four canonical nucleic acid bases. In contrast, in the presence of the external field the mispairing abilities of FAPy-adenine become insignificant since the most stable dimers are formed with thymine.[1]
In vivo
There is an increased trend in the levels of FAPy-adenine in the AD brain. The nuclear DNA damage by oxygen-derived radicals is increased in Alzheimer's disease and support the concept that the brain is under increased oxidative stress in Alzheimer's disease.[1]
Alias4,6-diamino-5-n-formamidopyrimidine
Chemical Properties
Molecular Weight153.14
FormulaC5H7N5O
Cas No.5122-36-1
SmilesO=CNC=1C(=NC=NC1N)N
Relative Density.1.575 g/cm3
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 15 mg/mL (97.95 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM6.5300 mL32.6499 mL65.2997 mL326.4986 mL
5 mM1.3060 mL6.5300 mL13.0599 mL65.2997 mL
10 mM0.6530 mL3.2650 mL6.5300 mL32.6499 mL
20 mM0.3265 mL1.6325 mL3.2650 mL16.3249 mL
50 mM0.1306 mL0.6530 mL1.3060 mL6.5300 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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