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FAPy-adenine

Name: FAPy-adenine
Brand: TargetMol
SKU: T19320
Price: 87 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T19320Cas No. 5122-36-1

FAPy-adenine, an oxidized DNA base, is increasingly found in the brains of people with Alzheimer's disease. Nucleoside oxidation, including that of adenine, serves as a biochemical marker for tumors, senescence, and neurodegenerative diseases.

FAPy-adenine

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Catalog No. T19320Cas No. 5122-36-1

Pack Size	Price	Availability
5 mg	$87	In Stock
10 mg	$140	In Stock
1 mL x 10 mM (in DMSO)	$154	In Stock

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Product Introduction

Bioactivity

Description	FAPy-adenine, an oxidized DNA base, is increasingly found in the brains of people with Alzheimer's disease. Nucleoside oxidation, including that of adenine, serves as a biochemical marker for tumors, senescence, and neurodegenerative diseases.
In vitro	In the absence of the external field the FAPy-adenine is able to form pairs with all four canonical nucleic acid bases.?In contrast, in the presence of the external field the mispairing abilities of FAPy-adenine become insignificant since the most stable dimers are formed with thymine
In vivo	Oxygen-derived radicals exacerbate nuclear DNA damage in Alzheimer's disease, reinforcing the notion that the brain endures heightened oxidative stress in this condition.

Chemical Properties

Molecular Weight	153.14
Formula	C₅H₇N₅O
Cas No.	5122-36-1
Relative Density.	1.575 g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice./Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Human Endogenous MetaboliteFAPy-adenineFAPyadenineFAPy adenine