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FAPy-adenine (4,6-diamino-5-N-formamidopyrimidine) is an oxidised DNA base, and its levels in the brains of Alzheimer's disease patients show an upward trend.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $87 | In Stock | |
10 mg | $140 | In Stock | |
1 mL x 10 mM (in DMSO) | $154 | In Stock |
Description | FAPy-adenine (4,6-diamino-5-N-formamidopyrimidine) is an oxidised DNA base, and its levels in the brains of Alzheimer's disease patients show an upward trend. |
In vitro | In the absence of the external field the FAPy-adenine is able to form pairs with all four canonical nucleic acid bases. In contrast, in the presence of the external field the mispairing abilities of FAPy-adenine become insignificant since the most stable dimers are formed with thymine.[1] |
In vivo | There is an increased trend in the levels of FAPy-adenine in the AD brain. The nuclear DNA damage by oxygen-derived radicals is increased in Alzheimer's disease and support the concept that the brain is under increased oxidative stress in Alzheimer's disease.[1] |
Alias | 4,6-diamino-5-n-formamidopyrimidine |
Molecular Weight | 153.14 |
Formula | C5H7N5O |
Cas No. | 5122-36-1 |
Smiles | O=CNC=1C(=NC=NC1N)N |
Relative Density. | 1.575 g/cm3 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 15 mg/mL (97.95 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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