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Perillyl alcohol

Name: Perillyl alcohol
Brand: TargetMol
SKU: T3314
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3314Cas No. 536-59-4

Alias Perilla alcohol, Isocarveol

Perillyl Alcohol is a naturally occurring monoterpene related to limonene with antineoplastic activity. Perillyl alcohol (Isocarveol) inhibits farnesyl transferase and geranylgeranyl transferase, thereby preventing post-translational protein farnesylation and isoprenylation and activation of oncoproteins such as p21-ras, and arresting tumor cells in the G1 phase of the cell cycle.

Perillyl alcohol

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Purity: 97.36%

Catalog No. T3314Alias Perilla alcohol, IsocarveolCas No. 536-59-4

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$34	In Stock	In Stock
500 mg	$55	In Stock	In Stock
1 g	$78	-	In Stock
1 mL x 10 mM (in DMSO)	$30	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.36%

Appearance:Liquid

Color:Transparent

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COA HNMR HPLC

Product Introduction

Perillyl alcohol AI Summary

Perillyl alcohol exhibits bioactivity across various assays and targets, demonstrating notable inhibitory potencies. It inhibits 15-human lipoxygenase with a potency of 12589.3 nM and displays a potency of 44668.4 nM in general anesthetic identification assays. The compound also inhibits Vaccinia Orthopoxvirus in a specific stage with a potency of 5011.9 nM. Additionally, it inhibits the recombinant human CYP1B1 enzyme with a Ki value of 2000.0 nM using ethoxyresorufin as a substrate after 20 minutes in the presence of NADPH in a fluorescence assay. Perillyl alcohol also demonstrates inhibitory activity against the SARS-CoV-2 3CL-Pro protease with an inhibition rate of 13.64% at a concentration of 20µM. Furthermore, it shows antiviral activity against SARS-CoV-2 by inhibiting virus-induced cytotoxicity in VERO-6 cells, with an IC50 value greater than 20,000 nM and an inhibition rate of -0.13% at 10 µM after 48 hours exposure. In human HDAC6 enzymatic assays, the compound shows an inhibition rate of 25.87% with a commercial peptide substrate but a decrease in inhibition of -11.12% with a custom peptide substrate. These findings suggest that Perillyl alcohol has multifaceted inhibitory properties relevant to inflammation, cancer, viral infections, and potential therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Perillyl Alcohol is a naturally occurring monoterpene related to limonene with antineoplastic activity. Perillyl alcohol (Isocarveol) inhibits farnesyl transferase and geranylgeranyl transferase, thereby preventing post-translational protein farnesylation and isoprenylation and activation of oncoproteins such as p21-ras, and arresting tumor cells in the G1 phase of the cell cycle.
Synonyms	Perilla alcohol, Isocarveol

Chemical Properties

Molecular Weight	152.23
Formula	C₁₀H₁₆O
Cas No.	536-59-4
Smiles	CC(=C)C1CCC(CO)=CC1
Relative Density.	0.94g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight,store under nitrogen | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (1642.25 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (13.14 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.5690 mL	32.8450 mL	65.6901 mL	328.4504 mL
5 mM	1.3138 mL	6.5690 mL	13.1380 mL	65.6901 mL
10 mM	0.6569 mL	3.2845 mL	6.5690 mL	32.8450 mL
20 mM	0.3285 mL	1.6423 mL	3.2845 mL	16.4225 mL
50 mM	0.1314 mL	0.6569 mL	1.3138 mL	6.5690 mL
100 mM	0.0657 mL	0.3285 mL	0.6569 mL	3.2845 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc