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Enflurane

Name: Enflurane
Brand: TargetMol
SKU: T19658
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T19658Cas No. 13838-16-9

Alias NSC-115944, NSC115944, NSC 115944, Ethrane, Efrane

Enflurane (Efrane), a volatile anaesthetic, is a potent inhibitor of high conductance Ca2+-activated K+ channels of Chara australis. Enflurane is an internal standard in monitoring halogenated volatile anaesthetics by headspace gas chromatography-mass spectrometry. It allows rapid adjustments of anesthesia depth with little change in pulse or respiratory rate.

Enflurane

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Purity: 99.64%

Catalog No. T19658Alias NSC-115944, NSC115944, NSC 115944, Ethrane, EfraneCas No. 13838-16-9

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$30	In Stock	In Stock
100 mg	$41	-	In Stock
500 mg	$97	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.64%

Appearance:Liquid

Color:Transparent

Resource Download

COA HNMR LCMS FNMR

Product Introduction

Enflurane AI Summary

Enflurane is characterized by its ability to cross the blood-brain barrier, indicated by a brain to blood partition coefficient (logBB) value of 0.24. It has anesthetic properties, with minimum alveolar concentrations (MAC) of 2.06 in dogs and 1.68 in humans, and displays a high oil/gas partition coefficient of 98.0. In terms of distribution within the body, it shows moderate partition coefficients between blood and lung, with logP(lung) = 0.21, logK(blood) = 0.35, and logK(lung) = 0.56. The compound exhibits bioactivities related to hepatic side effects, with a composite HepSE score of 2.0, indicating potential impacts on liver health such as hepatic failure and necrosis. It is also characterized by moderate liver toxicity, including cytolytic and cholestatic liver toxicity, granulomatous hepatitis, and acute liver toxicity. Additionally, Enflurane shows antiviral activity against SARS-CoV-2. It inhibits the virus-induced cytotoxicity in both Caco-2 cells (7.47% inhibition at 10 µM) and Vero-6 cells, though with negligible effect at the latter. It also inhibits the SARS-CoV-2 3CL-Pro protease with an inhibition percentage of 17.5% at 20 µM. Lastly, it shows inhibitory activity against human HDAC6 with inhibition percentages of -7.61% and -5.78% using different peptide substrates. The compound also shows activity in the Schwann cell PMP22 intronic element firefly luciferase assay, with a potency of 20314.8 nM. Further evaluation is required to fully understand the therapeutic potential and safety profile of Enflurane across these diverse bioactivities..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Enflurane (Efrane), a volatile anaesthetic, is a potent inhibitor of high conductance Ca2+-activated K+ channels of Chara australis. Enflurane is an internal standard in monitoring halogenated volatile anaesthetics by headspace gas chromatography-mass spectrometry. It allows rapid adjustments of anesthesia depth with little change in pulse or respiratory rate.
Synonyms	NSC-115944, NSC115944, NSC 115944, Ethrane, Efrane

Chemical Properties

Molecular Weight	184.49
Formula	C₃H₂ClF₅O
Cas No.	13838-16-9
Smiles	FC(F)OC(F)(F)C(F)Cl
Relative Density.	1.517 g/cm3

Storage & Solubility Information

Storage

store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (298.12 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.4203 mL	27.1017 mL	54.2035 mL	271.0174 mL
5 mM	1.0841 mL	5.4203 mL	10.8407 mL	54.2035 mL
10 mM	0.5420 mL	2.7102 mL	5.4203 mL	27.1017 mL
20 mM	0.2710 mL	1.3551 mL	2.7102 mL	13.5509 mL
50 mM	0.1084 mL	0.5420 mL	1.0841 mL	5.4203 mL
100 mM	0.0542 mL	0.2710 mL	0.5420 mL	2.7102 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc