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NRX-103095

Name: NRX-103095
Brand: TargetMol
SKU: T63730
Price: 153 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T63730Cas No. 2763260-38-2

NRX-103095 is a potent enhancer of the interaction of β-catenin with the homologous E3 ligase SCFβ-TrCP and enhances the affinity of pSer33/Ser37 β-catenin for β-TrCP with an EC50 of 163 nM.

NRX-103095

🥰Excellent

Purity: 99.95%

Catalog No. T63730Cas No. 2763260-38-2

NRX-103095 is a potent enhancer of the interaction of β-catenin with the homologous E3 ligase SCFβ-TrCP and enhances the affinity of pSer33/Ser37 β-catenin for β-TrCP with an EC50 of 163 nM.

Pack Size	Price	Availability
1 mg	$153	In Stock
5 mg	$383	In Stock
10 mg	$619	In Stock
25 mg	$1,230	In Stock
50 mg	$1,980	In Stock
100 mg	$2,970	In Stock
1 mL x 10 mM (in DMSO)	$449	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.95%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description

NRX-103095 is a potent enhancer of the interaction of β-catenin with the homologous E3 ligase SCFβ-TrCP and enhances the affinity of pSer33/Ser37 β-catenin for β-TrCP with an EC50 of 163 nM.

Chemical Properties

Molecular Weight	530.35
Formula	C₂₂H₁₆Cl₂F₃N₃O₃S
Cas No.	2763260-38-2
Smiles	S(C1=C(C(NC2=CC(C(N(C)C)=O)=CC=C2)=O)C(=O)NC(C(F)(F)F)=C1)C3=C(Cl)C=CC=C3Cl

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (169.7 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8855 mL	9.4277 mL	18.8555 mL	94.2774 mL
5 mM	0.3771 mL	1.8855 mL	3.7711 mL	18.8555 mL
10 mM	0.1886 mL	0.9428 mL	1.8855 mL	9.4277 mL
20 mM	0.0943 mL	0.4714 mL	0.9428 mL	4.7139 mL
50 mM	0.0377 mL	0.1886 mL	0.3771 mL	1.8855 mL
100 mM	0.0189 mL	0.0943 mL	0.1886 mL	0.9428 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc