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Anisodamine

Name: Anisodamine
Brand: TargetMol
SKU: T21532
Price: 97 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T21532Cas No. 55869-99-3

Alias 6-Hydroxyhyoscyamine, 6-beta-Hydroxyhyoscyamine

Anisodamine (6-beta-Hydroxyhyoscyamine) is an antagonist of muscarinic and nicotinic cholinoceptor with similar affinities at the muscarinic receptor as scopolamine and atropine. Anisodamine improve the microcirculation in states of shock and can be used in studies about organophosphate poisoning.

Anisodamine

🥰Excellent

Purity: 98.16%

Catalog No. T21532Alias 6-Hydroxyhyoscyamine, 6-beta-HydroxyhyoscyamineCas No. 55869-99-3

Pack Size	Price	Availability
1 mg	$97	In Stock
5 mg	$313	In Stock
10 mg	$468	In Stock
25 mg	$753	In Stock
50 mg	$987	In Stock
100 mg	$1,390	In Stock
500 mg	$2,790	In Stock
1 mL x 10 mM (in DMSO)	$278	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:98.16%

ee:100%

Resource Download

COA HNMR CSFC HPLC

Product Introduction

Bioactivity

Description	Anisodamine (6-beta-Hydroxyhyoscyamine) is an antagonist of muscarinic and nicotinic cholinoceptor with similar affinities at the muscarinic receptor as scopolamine and atropine. Anisodamine improve the microcirculation in states of shock and can be used in studies about organophosphate poisoning.
In vitro	In RAW264.7 cells, Anisodamine (100 μg/mL) blocks muscarinic receptors thus allowing more endogenous ACh binding to the α-7nAChR and attenuating α-bungarotoxin binding[3].
In vivo	Intraperitoneal administration of Anisodamine (50 mg/kg) significantly reduces mortality of LPS-induced shock mice(20%)[3].
Synonyms	6-Hydroxyhyoscyamine, 6-beta-Hydroxyhyoscyamine

Chemical Properties

Molecular Weight	305.37
Formula	C₁₇H₂₃NO₄
Cas No.	55869-99-3
Smiles	CN1[C@@H]2C[C@H](O)[C@H]1C[C@H](C2)OC(=O)[C@H](CO)c1ccccc1
Relative Density.	1.27
Color	Yellow
Appearance	Oil

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (294.72 mM), Sonication is recommended.

H2O: 18 mg/mL (58.94 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (10.81 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2747 mL	16.3736 mL	32.7472 mL	163.7358 mL
5 mM	0.6549 mL	3.2747 mL	6.5494 mL	32.7472 mL
10 mM	0.3275 mL	1.6374 mL	3.2747 mL	16.3736 mL
20 mM	0.1637 mL	0.8187 mL	1.6374 mL	8.1868 mL
50 mM	0.0655 mL	0.3275 mL	0.6549 mL	3.2747 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0327 mL	0.1637 mL	0.3275 mL	1.6374 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc