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Adomeglivant

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Catalog No. T14130Cas No. 1488363-78-5

Alias LY2409021

Adomeglivant (LY2409021) is a potent and selective glucagon receptor antagonist. Which is used in clinical trial for type 2 diabetes mellitus.

Adomeglivant

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Purity: 99.51%

Catalog No. T14130Alias LY2409021Cas No. 1488363-78-5

Adomeglivant (LY2409021) is a potent and selective glucagon receptor antagonist. Which is used in clinical trial for type 2 diabetes mellitus.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$32	-	In Stock
5 mg	$73	-	In Stock
10 mg	$123	-	In Stock
25 mg	$198	-	In Stock
50 mg	$372	-	In Stock
100 mg	$619	-	In Stock
1 mL x 10 mM (in DMSO)	$89	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.51%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Adomeglivant AI Summary

Adomeglivant demonstrates strong antiviral activity against SARS-CoV-2, with an inhibition rate of 91.53% at a concentration of 10 µM. It exhibits a high selectivity index of 3.13, indicating a preference for inhibiting virus-induced cytotoxicity in VERO-E6 cells over general cellular toxicity. The IC50 value for the inhibition of SARS-CoV-2-induced cytotoxicity is measured at 10550.0 nM, while the CC50 toxicity level against VERO-E6 cells is greater than 33000.0 nM. In addition, Adomeglivant has been reported to show activity as a 3CL-Pro protease inhibitor, although it demonstrated a low inhibition percentage of -2.88% at 20 µM in a FRET assay. It also inhibits the human glucagon receptor with a Ki value of 6.6 nM, suggesting potential as a glucagon receptor antagonist or inhibitor..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Adomeglivant (LY2409021) is a potent and selective glucagon receptor antagonist. Which is used in clinical trial for type 2 diabetes mellitus.
Synonyms	LY2409021

Chemical Properties

Molecular Weight	555.63
Formula	C₃₂H₃₆F₃NO₄
Cas No.	1488363-78-5
Smiles	Cc1cc(O[C@@H](CCC(F)(F)F)c2ccc(cc2)C(=O)NCCC(O)=O)cc(C)c1-c1ccc(cc1)C(C)(C)C
Relative Density.	1.173 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (161.98 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (5.94 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7998 mL	8.9988 mL	17.9976 mL	89.9879 mL
5 mM	0.3600 mL	1.7998 mL	3.5995 mL	17.9976 mL
10 mM	0.1800 mL	0.8999 mL	1.7998 mL	8.9988 mL
20 mM	0.0900 mL	0.4499 mL	0.8999 mL	4.4994 mL
50 mM	0.0360 mL	0.1800 mL	0.3600 mL	1.7998 mL
100 mM	0.0180 mL	0.0900 mL	0.1800 mL	0.8999 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc