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KL-11743

Name: KL-11743
Brand: TargetMol
SKU: T9558
Price: 115 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9558Cas No. 1369452-53-8

KL-11743 specifically blocks glucose metabolism, triggering an acute collapse in NADH pools and a striking accumulation of aspartate, indicating a dramatic shift toward oxidative phosphorylation in the mitochondria.

KL-11743

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Purity: 99.57%

Catalog No. T9558Cas No. 1369452-53-8

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$115	In Stock	In Stock
5 mg	$247	In Stock	In Stock
10 mg	$397	In Stock	In Stock
25 mg	$663	In Stock	In Stock
50 mg	$945	In Stock	In Stock
100 mg	$1,280	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$283	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.57%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HNMR HPLC LCMS

Product Introduction

Bioactivity

Description	KL-11743 specifically blocks glucose metabolism, triggering an acute collapse in NADH pools and a striking accumulation of aspartate, indicating a dramatic shift toward oxidative phosphorylation in the mitochondria.
Targets&IC50	GLUT2:137 nM (IC50), GLUT1:115 nM (IC50), GLUT3:90 nM (IC50), GLUT4:68 nM (IC50)
In vitro	Patient-derived xenograft models of succinate dehydrogenase A (SDHA)-deficient cancers are specifically sensitive to KL-11743, providing direct evidence that TCA cycle-mutant tumors are vulnerable to GLUT inhibitors in vivo[1].

Chemical Properties

Molecular Weight	522.6
Formula	C₃₀H₃₀N₆O₃
Cas No.	1369452-53-8
Smiles	CCOc1ccc2nc(nc(Nc3ccc(cc3)-c3cn[nH]c3)c2c1)-c1cccc(OCC(=O)NC(C)C)c1
Relative Density.	1.259 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 14 mg/mL (26.79 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2 mg/mL (3.83 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9135 mL	9.5675 mL	19.1351 mL	95.6755 mL
5 mM	0.3827 mL	1.9135 mL	3.8270 mL	19.1351 mL
10 mM	0.1914 mL	0.9568 mL	1.9135 mL	9.5675 mL
20 mM	0.0957 mL	0.4784 mL	0.9568 mL	4.7838 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc