Shopping Cart

Your shopping cart is currently empty

Tyrphostin A1

Name: Tyrphostin A1
Brand: TargetMol
SKU: T7649
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

😃Good

Catalog No. T7649Cas No. 2826-26-8

Alias Tyrphostin 1, AG9

Tyrphostin A1 (Tyrphostin 1) is an inhibitor of EGFR tyrosine kinase .

Tyrphostin A1

😃Good

Purity: 98.32%

Catalog No. T7649Alias Tyrphostin 1, AG9Cas No. 2826-26-8

Tyrphostin A1 (Tyrphostin 1) is an inhibitor of EGFR tyrosine kinase .

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$30	-	In Stock
25 mg	$53	-	In Stock
50 mg	$76	-	In Stock
100 mg	$98	-	In Stock
200 mg	$143	-	In Stock
1 mL x 10 mM (in DMSO)	$29	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:98.32%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Tyrphostin A1 (Tyrphostin 1) is an inhibitor of EGFR tyrosine kinase .
In vitro	Tyrphostin A1 inhibits CD40L-stimulated IL-12 production in macrophage cultures and antigen-induced generation of Th1 cells.tyrphostin A1 blocks CD40L-induced translocation of NF-kappaB to the nucleus, and reduces the activation of IL-12 p40 gene.?In vivo therapy with A1 leads to decrease in generation of myelin basic protein (MBP) specific encephalitogenic T cells[1].
Synonyms	Tyrphostin 1, AG9

Chemical Properties

Molecular Weight	184.19
Formula	C₁₁H₈N₂O
Cas No.	2826-26-8
Smiles	COC1=CC=C(C=C(C#N)C#N)C=C1
Relative Density.	1.169 g/cm3 (Predicted)
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (542.92 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (17.92 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.4292 mL	27.1459 mL	54.2918 mL	271.4588 mL
5 mM	1.0858 mL	5.4292 mL	10.8584 mL	54.2918 mL
10 mM	0.5429 mL	2.7146 mL	5.4292 mL	27.1459 mL
20 mM	0.2715 mL	1.3573 mL	2.7146 mL	13.5729 mL
50 mM	0.1086 mL	0.5429 mL	1.0858 mL	5.4292 mL
100 mM	0.0543 mL	0.2715 mL	0.5429 mL	2.7146 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc