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Tyrphostin A1
🥰Excellent
Catalog No. T7649Cas No. 2826-26-8
Alias Tyrphostin 1, AG9
Tyrphostin A1 (Tyrphostin 1) is an inhibitor of EGFR tyrosine kinase .
Tyrphostin A1
🥰Excellent
Purity: 98.32%
Catalog No. T7649Alias Tyrphostin 1, AG9Cas No. 2826-26-8
Tyrphostin A1 (Tyrphostin 1) is an inhibitor of EGFR tyrosine kinase .
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | $30 | - | In Stock | |
| 25 mg | $53 | - | In Stock | |
| 50 mg | $76 | - | In Stock | |
| 100 mg | $98 | - | In Stock | |
| 200 mg | $143 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $29 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.32%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Tyrphostin A1 (Tyrphostin 1) is an inhibitor of EGFR tyrosine kinase . |
| In vitro | Tyrphostin A1 inhibits CD40L-stimulated IL-12 production in macrophage cultures and antigen-induced generation of Th1 cells.tyrphostin A1 blocks CD40L-induced translocation of NF-kappaB to the nucleus, and reduces the activation of IL-12 p40 gene.?In vivo therapy with A1 leads to decrease in generation of myelin basic protein (MBP) specific encephalitogenic T cells[1]. |
| Synonyms | Tyrphostin 1, AG9 |
| Molecular Weight | 184.19 |
| Formula | C11H8N2O |
| Cas No. | 2826-26-8 |
| Smiles | COC1=CC=C(C=C(C#N)C#N)C=C1 |
| Relative Density. | 1.169 g/cm3 (Predicted) |
| Color | Yellow |
| Appearance | Solid |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (542.92 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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