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Anti-UCHL1 Antibody (3J819)
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Catalog No. TMAY-03401
Alias ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
Anti-UCHL1 Antibody (3J819) is a Rabbit antibody targeting UCHL1. Anti-UCHL1 Antibody (3J819) can be used in ELISA.
Anti-UCHL1 Antibody (3J819)
Anti-UCHL1 Antibody (3J819)
😃Good
Catalog No. TMAY-03401Alias ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
Anti-UCHL1 Antibody (3J819) is a Rabbit antibody targeting UCHL1. Anti-UCHL1 Antibody (3J819) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $269 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-UCHL1 Antibody (3J819) is a Rabbit antibody targeting UCHL1. Anti-UCHL1 Antibody (3J819) can be used in ELISA. |
| Alias | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 3J819 |
| Reactivity | Mouse |
| Application | ELISA |
| Recommended Dose | ELISA: 1:5000-1:10000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse UCHL1 (rM UCHL1; TMPY-02175; Q9R0P9; Gln 2-Ala 223). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Ubiquitin carboxyl-terminal hydrolase isozyme L1, also known as UCH-L1, Ubiquitin thioesterase L1, PGP9.5 and UCHL1, is a deubiqutinating enzyme with important functions in recycling of ubiquitin. Regulated proteolysis by the ubiquitin pathway has been implicated in control of the cell cycle, transcriptional activation, cell fate and growth, and synaptogenesis. The ubiquitin-proteasome system is involved in synaptic plasticity and is proposed to be part of a molecular switch that converts short-term synaptic potentiation to long-term changes in synaptic strength. UCHL1 is found in neuronal cell bodies and processes throughout the neocortex (at protein level). It is expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. UCHL1 is weakly expressed in ovary. UCHL1 is a ubiquitin-protein hydrolase. It is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. UCHL1 also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer of UCHL1 may have ATP-independent ubiquitin ligase activity. UCHL1 dysfunction has been associated with neurodegeneration in Parkinson's, Alzheimer's, and Huntington's disease patients. Reduced UCHL1 function may jeopardize the survival of CNS neurons. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Mouse UCHL1 protein (TMPY-02175) |
| Antigen Species | Mouse |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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