Laromustine

Name: Laromustine
Brand: TargetMol
SKU: T70229
Price: 293 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T70229Cas No. 173424-77-6

Alias VNP40101M, VNP 40101M

Laromustine (VNP40101M) is a sulfonyl hydrolytic alkylating prodrug used in cancer therapy with significant anticancer activity.
Inhibiting thioredoxin reductase can be used to study acute myeloid leukemia.

Laromustine

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Catalog No. T70229Alias VNP40101M, VNP 40101MCas No. 173424-77-6

Pack Size	Price	Availability
1 mg	$293	In Stock
5 mg	$722	In Stock
10 mg	$987	In Stock
25 mg	$1,520	In Stock
50 mg	$1,980	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:≥98%

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COA CNMR HNMR

Product Introduction

Bioactivity

Description	Laromustine (VNP40101M) is a sulfonyl hydrolytic alkylating prodrug used in cancer therapy with significant anticancer activity. Inhibiting thioredoxin reductase can be used to study acute myeloid leukemia.
Targets&IC50	CYP2B6:125 mM (Ki), CYP3A4/5:297 mM (Ki), CYP2C19:349 mM (ki)
In vitro	Laromustine caused direct inhibition of CYP2B6 and CYP3A4/5 as well as of CYP2C19. CYP2B6 K(i)=125 mM, CYP3A4/5 K(i)=297 mM, and CYP2C19 K(i)=349 mM and were greater than the average clinical plasma C(max) of Laromustine (C(max)=25 mM). [1]
Synonyms	VNP40101M, VNP 40101M

Chemical Properties

Molecular Weight	307.78
Formula	C₆H₁₄ClN₃O₅S₂
Cas No.	173424-77-6
Smiles	O=C(NC)N(N(CCCl)S(=O)(=O)C)S(=O)(=O)C
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

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