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AzddMeC

Name: AzddMeC
Brand: TargetMol
SKU: T26726
Price: 43 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T26726Cas No. 87190-79-2

Alias CS-92, Azidodideoxymethylcytidine, Az-Dcme

AzddMeC (Az-Dcme) is a nucleoside analog with antiviral activity and is an orally active and selective inhibitor of HIV-1 reverse transcriptase and HIV-1 replication.AzddMeC has an EC50 value of 9 nM against HIV-1-infected human PBM cells and 6 nM against HIV-1-infected human macrophages.

AzddMeC

🥰Excellent

Purity: 99.62%

Catalog No. T26726Alias CS-92, Azidodideoxymethylcytidine, Az-DcmeCas No. 87190-79-2

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$43	In Stock	In Stock
5 mg	$103	In Stock	In Stock
10 mg	$167	In Stock	In Stock
25 mg	$337	In Stock	In Stock
50 mg	$535	In Stock	In Stock
100 mg	$893	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.62%

ee:100%

Appearance:Solid

Color:Yellow

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COA CSFC HNMR LCMS

Product Introduction

Bioactivity

Description	AzddMeC (Az-Dcme) is a nucleoside analog with antiviral activity and is an orally active and selective inhibitor of HIV-1 reverse transcriptase and HIV-1 replication.AzddMeC has an EC50 value of 9 nM against HIV-1-infected human PBM cells and 6 nM against HIV-1-infected human macrophages.
Targets&IC50	HIV-1:6 nM (EC50, Human macrophages), HIV-1:9 nM (EC50, Human PBM cells)
In vitro	AzddMeC emerged as the most potent inhibitor of hepatitis B virus DNA polymerase (50% inhibitor dose, 0.03-0.35 μM). In contrast, cellular DNA polymerase was shown to be resistant to or partially (β) affected by AzddMeC. [4]
In vivo	Following intravenously and orally administered 60 mg/kg AzddMeC to male rhesus monkeys, 3'-azido-3'-deoxythymidine (AZT) was found to be the major metabolite of AzddMeC in monkeys. Serum concentrations of AzddMeC decreased rapidly in a biexponential manner with terminal half-lives ranging from 0.5 to 1.3 h. Total clearance of AzddMeC was 2.00 +/- 0.41 l/h/kg (mean +/- standard deviation) and the fraction of AzddMeC metabolized to AZT was 0.32 +/- 0.05. The total clearance was 2.00 +/- 0.41 l/h/kg (mean +/- standard deviation).[2]
Synonyms	CS-92, Azidodideoxymethylcytidine, Az-Dcme

Chemical Properties

Molecular Weight	266.26
Formula	C₁₀H₁₄N₆O₃
Cas No.	87190-79-2
Smiles	Cc1cn([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)c(=O)nc1N
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (375.57 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7557 mL	18.7786 mL	37.5573 mL	187.7864 mL
5 mM	0.7511 mL	3.7557 mL	7.5115 mL	37.5573 mL
10 mM	0.3756 mL	1.8779 mL	3.7557 mL	18.7786 mL
20 mM	0.1878 mL	0.9389 mL	1.8779 mL	9.3893 mL
50 mM	0.0751 mL	0.3756 mL	0.7511 mL	3.7557 mL
100 mM	0.0376 mL	0.1878 mL	0.3756 mL	1.8779 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc