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Azido-PEG16-NHS ester is a PEG-based linker utilized in the synthesis of PROTACs (proteolysis-targeting chimeras), facilitating the conjugation of two essential ligands necessary for PROTAC formation and enabling selective protein degradation via the ubiquitin-proteasome system within cells.
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500 mg | Inquiry | Backorder |
Description | Azido-PEG16-NHS ester is a PEG-based linker utilized in the synthesis of PROTACs (proteolysis-targeting chimeras), facilitating the conjugation of two essential ligands necessary for PROTAC formation and enabling selective protein degradation via the ubiquitin-proteasome system within cells. |
In vitro | PROTACs consist of two ligands linked together: one binds to an E3 ubiquitin ligase, while the other targets a specific protein. They leverage the intracellular ubiquitin-proteasome system to selectively degrade these target proteins [1]. |
Molecular Weight | 917 |
Formula | C39H72N4O20 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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