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TC ASK 10

🥰Excellent
Catalog No. T13099Cas No. 1005775-56-3

TC ASK 10 is a potent, selective and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1,IC50 = 14 nM). The IC50 value for ASK2 is 0.51 μM.

TC ASK 10

TC ASK 10

🥰Excellent
Purity: 99.86%
Catalog No. T13099Cas No. 1005775-56-3
TC ASK 10 is a potent, selective and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1,IC50 = 14 nM). The IC50 value for ASK2 is 0.51 μM.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$29In StockIn Stock
5 mg$83In StockIn Stock
10 mg$133In StockIn Stock
25 mg$263In StockIn Stock
50 mg$413In StockIn Stock
100 mg$592In StockIn Stock
200 mg$783In StockIn Stock
1 mL x 10 mM (in DMSO)$92In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:99.86%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
TC ASK 10 is a potent, selective and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1,IC50 = 14 nM). The IC50 value for ASK2 is 0.51 μM.
Targets&IC50
ASK2:0.51 μM, ASK1:14 nM
In vitro
Streptozotocin (STZ)-induced JNK in INS-1 pancreatic β cells from 0.3 μM inhibited by TC ASK 10 (0-10 μM; 1 hour; INS-1 cells). Phosphorylation of p38 is also inhibited in a dosedependent manner.
In vivo
In rats, Pharmacokinetic profiles are tested. TC ASK 10 (rat cassette doing at 0.1 mg/kg, iv and 1 mg/kg, po.) has a good oral bioavailability. The Cmax, Tmax and AUCpo,0-8h are 285.1 ng/mL, 1.67 h and 275.4 ng.h/mL, respectively for TC ASK 10.
Chemical Properties
Molecular Weight432.35
FormulaC21H23Cl2N5O
Cas No.1005775-56-3
SmilesCl.Cl.CC(C)(C)c1ccc(cc1)C(=O)Nc1cn2cc(ccc2n1)-n1ccnc1
Relative Density.1.31g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 100 mg/mL (231.29 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (9.25 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3129 mL11.5647 mL23.1294 mL115.6470 mL
5 mM0.4626 mL2.3129 mL4.6259 mL23.1294 mL
10 mM0.2313 mL1.1565 mL2.3129 mL11.5647 mL
20 mM0.1156 mL0.5782 mL1.1565 mL5.7824 mL
50 mM0.0463 mL0.2313 mL0.4626 mL2.3129 mL
100 mM0.0231 mL0.1156 mL0.2313 mL1.1565 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

TC ASK-10TC ASK10TC ASK 10selectivePhosphorylationpharmacokineticp38oralMAP3KMAP kinase kinase kinase, MEKK, MAPKKKJNKInhibitorinhibitbioavailabilityASK2ASK1Apoptosis
Related Tags: buy TC ASK 10 | purchase TC ASK 10 | TC ASK 10 cost | order TC ASK 10 | TC ASK 10 chemical structure | TC ASK 10 in vivo | TC ASK 10 in vitro | TC ASK 10 formula | TC ASK 10 molecular weight
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