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Anti-Glucocorticoid receptor Antibody (1B847)
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Catalog No. TMAB-06533
Anti-Glucocorticoid receptor Antibody (1B847) is a Mouse antibody targeting Glucocorticoid receptor. Anti-Glucocorticoid receptor Antibody (1B847) can be used in WB.
Anti-Glucocorticoid receptor Antibody (1B847)
Anti-Glucocorticoid receptor Antibody (1B847)
😃Good
Catalog No. TMAB-06533
Anti-Glucocorticoid receptor Antibody (1B847) is a Mouse antibody targeting Glucocorticoid receptor. Anti-Glucocorticoid receptor Antibody (1B847) can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $221 | 7-10 days | 7-10 days | |
| 100 μL | $371 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Glucocorticoid receptor Antibody (1B847) is a Mouse antibody targeting Glucocorticoid receptor. Anti-Glucocorticoid receptor Antibody (1B847) can be used in WB. |
| Ig Type | IgG1, k |
| Clone | 1B847 |
| Reactivity | Human (predicted:Mouse,Hamster) |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Subcellular Localization | Cytoplasm. Nucleus. Note=Cytoplasmic in the absence of ligand, nuclear after ligand-binding. Isoform Beta: Nucleus. Note=Localized largely in the nucleus. |
| Tissue Specificity | Widely expressed. In the heart, detected in left and right atria, left and right ventricles, aorta, apex, intraventricular septum, and atrioventricular node as well as whole adult and fetal heart. |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Protein G purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Steroid receptors are ligand-dependent, intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone. Glucocorticoids are a family of steroids necessary for the regulation of energy metabolism and the immune and inflammatory responses. These compounds exert their effect through their interaction with the glucocoticoid receptor (GR) and that complex's subsequent association with DNA. All normal mammalian tissues examined to date have been shown to contain glucocorticoid receptor. |
| Immunogen | Recombinant Protein: human Glucocorticoid receptor |
| Antigen Species | Human |
| Gene Name | NR3C1 |
| Gene ID | |
| Protein Name | Glucocorticoid receptor |
| Uniprot ID | |
| Function | Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE) and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation. Involved in nuclear translocation. |
| Molecular Weight | Theoretical: 85 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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