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Sumatriptan

Name: Sumatriptan
Brand: TargetMol
SKU: T23405
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T23405Cas No. 103628-46-2

Alias GR 43175 free base

Sumatriptan (GR 43175 free base) is an orally active and potent 5-hydroxytryptamine 1 (5-HT1) receptor agonist that crosses the blood-brain barrier and has anti-inflammatory activity with high affinity for 5-HT1D, 5-HT1B, and 5-HT1F receptors for use in acute migraines and acute myocardial infarction.

Sumatriptan

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Purity: 99.93%

Catalog No. T23405Alias GR 43175 free baseCas No. 103628-46-2

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$30	In Stock	In Stock
25 mg	$45	In Stock	In Stock
50 mg	$62	In Stock	In Stock
100 mg	$89	In Stock	In Stock
500 mg	$213	-	In Stock
1 mL x 10 mM (in DMSO)	$34	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.93%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Sumatriptan (GR 43175 free base) is an orally active and potent 5-hydroxytryptamine 1 (5-HT1) receptor agonist that crosses the blood-brain barrier and has anti-inflammatory activity with high affinity for 5-HT1D, 5-HT1B, and 5-HT1F receptors for use in acute migraines and acute myocardial infarction.
Targets&IC50	5-HT1F Receptor:17.8 nM, 5-HT1A Receptor:100 nM (Ki), 5-HT1B Receptor:27 nM (Ki), 5-HT1B Receptor:9.3 nM, 5-HT1D Receptor:7.3 nM (IC50), 5-HT1D Receptor:17 nM (Ki)
Synonyms	GR 43175 free base

Chemical Properties

Molecular Weight	295.4
Formula	C₁₄H₂₁N₃O₂S
Cas No.	103628-46-2
Smiles	O=S(=O)(NC)CC=1C=CC=2NC=C(C2C1)CCN(C)C
Relative Density.	1.1778 g/cm3 (Estimated)

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 40 mg/mL (135.41 mM), Sonication is recommended.

DMSO: 80 mg/mL (270.82 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (11.17 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3852 mL	16.9262 mL	33.8524 mL	169.2620 mL
5 mM	0.6770 mL	3.3852 mL	6.7705 mL	33.8524 mL
10 mM	0.3385 mL	1.6926 mL	3.3852 mL	16.9262 mL
20 mM	0.1693 mL	0.8463 mL	1.6926 mL	8.4631 mL
50 mM	0.0677 mL	0.3385 mL	0.6770 mL	3.3852 mL
100 mM	0.0339 mL	0.1693 mL	0.3385 mL	1.6926 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc