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GLUT4-IN-2

Name: GLUT4-IN-2
Brand: TargetMol
SKU: T61695
Rating: 4.5 (1 reviews)

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Catalog No. T61695Cas No. 2454113-83-6

GLUT4-IN-2 is a specific GLUT4 inhibitor that inhibits GLUT1 and GLUT4.GLUT4-IN-2 has antitumor activity, induces apoptosis and cell cycle arrest, and can be used for cancer research.

GLUT4-IN-2

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Purity: 99.90%

Catalog No. T61695Cas No. 2454113-83-6

GLUT4-IN-2 is a specific GLUT4 inhibitor that inhibits GLUT1 and GLUT4.GLUT4-IN-2 has antitumor activity, induces apoptosis and cell cycle arrest, and can be used for cancer research.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
50 mg	$789	6-8 weeks	6-8 weeks
100 mg	$1,280	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.90%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	GLUT4-IN-2 is a specific GLUT4 inhibitor that inhibits GLUT1 and GLUT4.GLUT4-IN-2 has antitumor activity, induces apoptosis and cell cycle arrest, and can be used for cancer research.
Targets&IC50	KCL-22:15.3 µM （CC50）, K562 cells:91.9 µM （CC50）, HS-27:44.0 µM （CC50）, GLUT1:11.4 μM, CME:1.7 µM, MDA-MB-231 cells:45.1 µM （CC50）, GLUT4:6.8 μM
In vitro	In CME, K562, KCL-22, MB-231, and HS-27 cells, GLUT4-IN-2 (1-100 µM; 48 hours) exhibited potent cytotoxicity, with cytotoxic concentration 50% (CC50) values of 1.7, 91.9, 15.3, 45.1, and 44.0 µM for CME, K562, KCL-22, MB-231, and HS-27 cells, respectively[1].
In vivo	In 8-10 week old SCID mice (CEM xenograft tumor model), GLUT4-IN-2 (50 mg/kg; i.p.; administered on days 1-5, 8-12, 15-18) showed potent antitumor activity in vivo[1].

Chemical Properties

Molecular Weight	385.42
Formula	C₁₇H₁₁N₃O₄S₂
Cas No.	2454113-83-6
Smiles	O=C1SC(=CC=2OC=CC2)C(=O)N1CC(=O)NC3=NC=4C=CC=CC4S3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (207.57 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (8.56 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5946 mL	12.9729 mL	25.9457 mL	129.7286 mL
5 mM	0.5189 mL	2.5946 mL	5.1891 mL	25.9457 mL
10 mM	0.2595 mL	1.2973 mL	2.5946 mL	12.9729 mL
20 mM	0.1297 mL	0.6486 mL	1.2973 mL	6.4864 mL
50 mM	0.0519 mL	0.2595 mL	0.5189 mL	2.5946 mL
100 mM	0.0259 mL	0.1297 mL	0.2595 mL	1.2973 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc