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GLUT4-IN-2

Name: GLUT4-IN-2
Brand: TargetMol
SKU: T61695
Rating: 4.5 (1 reviews)

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Catalog No. T61695Cas No. 2454113-83-6

GLUT4-IN-2 is a specific GLUT4 inhibitor that inhibits GLUT1 and GLUT4.GLUT4-IN-2 has antitumor activity, induces apoptosis and cell cycle arrest, and can be used for cancer research.

GLUT4-IN-2

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Purity: 99.90%

Catalog No. T61695Cas No. 2454113-83-6

GLUT4-IN-2 is a specific GLUT4 inhibitor that inhibits GLUT1 and GLUT4.GLUT4-IN-2 has antitumor activity, induces apoptosis and cell cycle arrest, and can be used for cancer research.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
50 mg	$789	6-8 weeks	6-8 weeks
100 mg	$1,280	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.90%

Appearance:Solid

Color:Yellow

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	GLUT4-IN-2 is a specific GLUT4 inhibitor that inhibits GLUT1 and GLUT4.GLUT4-IN-2 has antitumor activity, induces apoptosis and cell cycle arrest, and can be used for cancer research.
Targets&IC50	GLUT4:6.8 μM, CME:1.7 µM, K562 cells:91.9 µM （CC50）, KCL-22:15.3 µM （CC50）, HS-27:44.0 µM （CC50）, MDA-MB-231 cells:45.1 µM （CC50）, GLUT1:11.4 μM
In vitro	In CME, K562, KCL-22, MB-231, and HS-27 cells, GLUT4-IN-2 (1-100 µM; 48 hours) exhibited potent cytotoxicity, with cytotoxic concentration 50% (CC50) values of 1.7, 91.9, 15.3, 45.1, and 44.0 µM for CME, K562, KCL-22, MB-231, and HS-27 cells, respectively[1].
In vivo	In 8-10 week old SCID mice (CEM xenograft tumor model), GLUT4-IN-2 (50 mg/kg; i.p.; administered on days 1-5, 8-12, 15-18) showed potent antitumor activity in vivo[1].

Chemical Properties

Molecular Weight	385.42
Formula	C₁₇H₁₁N₃O₄S₂
Cas No.	2454113-83-6
Smiles	O=C1SC(=CC=2OC=CC2)C(=O)N1CC(=O)NC3=NC=4C=CC=CC4S3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (207.57 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (8.56 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5946 mL	12.9729 mL	25.9457 mL	129.7286 mL
5 mM	0.5189 mL	2.5946 mL	5.1891 mL	25.9457 mL
10 mM	0.2595 mL	1.2973 mL	2.5946 mL	12.9729 mL
20 mM	0.1297 mL	0.6486 mL	1.2973 mL	6.4864 mL
50 mM	0.0519 mL	0.2595 mL	0.5189 mL	2.5946 mL
100 mM	0.0259 mL	0.1297 mL	0.2595 mL	1.2973 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc