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P32/98 (hemifumarate)

Catalog No. T21979 CAS 251572-86-8

P32/98 hemifumarateis a potent inhibitor of dipeptidyl peptidase IV with a K i value of 130 nM. P32/98 hemifumarate improves glucose tolerance, insulin sensitivity and β-cell responsiveness in fatty Zucker rat model. P32/98 has the potential to prevent type 2 diabetes [1] [2] [3].

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P32/98 (hemifumarate) Chemical Structure

P32/98 (hemifumarate), CAS 251572-86-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 93.00
5 mg	In stock	$ 228.00
10 mg	In stock	$ 342.00
25 mg	In stock	$ 568.00
50 mg	In stock	$ 812.00
100 mg	In stock	$ 1,090.00
500 mg	In stock	$ 2,180.00

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Purity: 99.07%

ee: 97.87%

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Description	P32/98 hemifumarateis a potent inhibitor of dipeptidyl peptidase IV with a K i value of 130 nM. P32/98 hemifumarate improves glucose tolerance, insulin sensitivity and β-cell responsiveness in fatty Zucker rat model. P32/98 has the potential to prevent type 2 diabetes [1] [2] [3].
In vitro	Following food intake, Glucagon-like peptide 1 (GLP-1) is released into the bloodstream, where it promotes glucose-dependent insulin secretion and induces feelings of satiety. The primary enzymatic pathway for GLP-1 breakdown in the body involves Dipeptidyl Peptidase-IV (DPPIV). Research demonstrates that the presence of P32/98 hemifumarate, in conjunction with 200 pM GLP-1 (10 μM; 3 h), does not significantly affect sodium re-absorption in porcine proximal tubular cells. Furthermore, treatment with P32/98 hemifumarate (10 μM; 96 h) does not alter the mRNA expression of GLP-1R, DPPIV, Na+/H+ exchanger isoform 3 (NHE3), or the sodium-dependent glucose transporters slc5a1 and slc5a2 (SGLT1, 2). A cell cytotoxicity assay conducted on porcine proximal tubular cells at a concentration of 10 μM for 96 hours revealed no toxic effects, affirming the compound's safety at the tested concentration and duration.
In vivo	Long-term administration of P32/98 hemifumarate (25 mg/kg; i.g.; once daily) significantly enhances glucose tolerance in Zucker diabetic fatty rats, which are a model of IGT (impaired glucose tolerance) [3]. This regimen involved oral gavage of the specified dose daily, demonstrating a noteworthy improvement in glucose tolerance within this animal model [3].

Molecular Weight	520.7
Formula	C22H40N4O6S2
CAS No.	251572-86-8

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

P32/98 (hemifumarate) 251572-86-8 P32/98 inhibitor inhibit

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