CD73 (Inhibitors Agonists Modulators Antagonists)

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Immunology/Inflammation

Aryl Hydrocarbon Receptor

Immunology/Inflammation related

NOD-like Receptor (NLR)

Prostaglandin Receptor

Reactive Oxygen Species

Thrombopoietin Receptor

CD73

5′-nucleotidase (5′-NT), also known CD73 (cluster of differentiation 73), is an enzyme that in humans is encoded by the NT5E gene. CD73 commonly serves to convert AMP to adenosine. NT5E (CD73) is a surface enzyme which is expressed on multiple cells. This enzyme mediates the gradual hydrolysis of the autocrine and paracrine danger signals of ATP and ADP to anti-inflammatory adenosine. Immune suppression mediated by adenosinergic pathways is very important for maintaining immune system homeostasis.

Oleclumab

MEDI-9447, MEDI9447, MED I9447

T766951803176-05-7

Oleclumab (MEDI9447) is a human anti-CD73 monoclonal antibody with anticancer activity that inhibits the extracellular enzyme CD73 nucleic acid exonuclease activity, inhibits the adenosine pathway, and can be used for the study of metastatic desmoplasia-resistant prostate cancer.

CD73

$479

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AB-680

T102162105904-82-1

AB-680, a highly potent, reversible, and selective inhibitor of CD73 (an ectonucleotidase, Ki: 4.9 pM for hCD73) with anti-tumor activity, displays >10,000-fold selectivity over related ectonucleotidases CD39.

CD73

$115

In Stock

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Cited

MethADP

Adenosine 5'-(α,β-methylene)diphosphate

T120083768-14-7In house

MethADP (Adenosine 5'-(α,β-methylene)diphosphate) is a specific CD73 inhibitor that inhibits the enzyme ecto-5′-nucleotidase (ecto), which has been used in the study of neurological and cardiovascular diseases.

CD73

$198

In Stock

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CD73-IN-3

LY-3475070, EX-A4254

T88752375815-63-5

CD73-IN-3 (LY-3475070) is a potent and selective CD73 inhibitor with an IC50 of 28 nM, and its use alone or in combination with pembrolizumab is currently being tested in patients with advanced cancer.

CD73

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CD73-IN-4

T92102216764-29-1

CD73-IN-4 is a potent and selective methylenephosphonic acid CD73 inhibitor.

CD73

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CD73-IN-1

T107212132396-40-6

CD73-IN-1 is a CD73 inhibitor with anticancer activity.

CD73

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PSB-12379 ditriethylamine salt

T12569LIn house

PSB-12379 ditriethylamine salt, a nucleotide analogue, is a potent Ecto-5'-Nucleotidase (CD73) inhibitor with Kis of 9.03 nM (rat) and 2.21 nM (human).

CD73

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Uliledlimab

TJ-004309, TJ004309

T767302378407-27-1

Uliledlimab is a humanized monoclonal antibody with potent inhibitory activity against CD73, the ecto-5'-nucleotidase enzyme that catalyzes the conversion of extracellular AMP to adenosine. Uliledlimab reduces extracellular adenosine production, thereby modulating immunosuppressive pathways. Uliledlimab holds significant potential for use in immuno-oncology and cancer research.

cAMP CD73

$339

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Mupadolimab

CPI-006

T767352451856-97-4

Mupadolimab (CPI-006) is a humanized FC-γR binding deficient IgG1 anti-CD73 antibody with potential anticancer activity and activation of CD73POS B cells.

CD73

$222

In Stock

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CD73-IN-5

T400332412019-99-7In house

CD73-IN-5 is a highly potent and selective small molecule inhibitor of CD73, demonstrating non-nucleotide characteristics. It exerts its inhibitory effects with a remarkable IC50 value of 19 nM.

CD73 Others

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COPCP trisodium

T212315

COPCP trisodium (Compound 7a) is a potent and selective inhibitor of the ecto-5'-nucleotidase CD73. By blocking CD73-mediated adenosine production, it reduces adenosine's inhibitory effects on immune cells. COPCP trisodium shows promise for cancer research.

CD73

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XC-12

T210749

XC-12 is an orally active, potent small-molecule inhibitor of CD73 (an immune checkpoint), with IC50 values of 12.36 nM for the soluble form and 1.29 nM for the membrane-bound form. XC-12 holds promise for cancer research.

CD73

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CD73-IN-7

T605992763709-14-2

CD73-IN-7 is a potent CD73 inhibitor used for preparing medications for tumor-related diseases. CD73 catalyzes the production of adenosine from extracellular 5'-phosphate adenosine (5'-AMP), inducing immunosuppressive effects and promoting tumor proliferation and/or metastasis [1].

CD73 Others

$1,520

10-14 weeks

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CD73-IN-8

T610902763710-08-1

CD73-IN-8, a potent CD73 inhibitor, prevents the catalytic activity of CD73, an enzyme responsible for converting extracellular 5'-phosphate adenosine (5'-AMP) to adenosine. Adenosine, once produced, can induce immunosuppressive effects and facilitate tumor proliferation and/or metastasis. Therefore, CD73-IN-8 holds promise in the development of therapeutic interventions for tumor-related diseases[1].

CD73 Others

$2,140

6-8 weeks

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CD73-IN-12

T61118

CD73-IN-12 is a highly effective CD73 inhibitor that displays strong potential in tumor suppression. CD73, an enzyme intricately linked to tumor development, angiogenesis, and metastasis, is significantly inhibited by CD73-IN-12. This compound holds promise in the formulation of therapeutic medications targeting tumor-related diseases[1].

CD73 Others

$1,520

10-14 weeks

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Dresbuxelimab

AK-119, AK119, AK 119

T806032550560-20-6

Dresbuxelimab (AK-119) is a humanized monoclonal antibody targeting CD73 that inhibits its exonuclease activity, applicable for COVID-19 research.

CD73

$166

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PSB-12379 disodium

T73628

PSB-12379 disodium is a nucleotide analogue acting as a potent inhibitor of Ecto-5'-Nucleotidase (CD73), demonstrating inhibitory constants (Ki) of 9.03 nM in rats and 2.21 nM in humans [1] [2].

CD73 Others

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ZM522

T2033411454575-38-2

ZM522 is a CD73 inhibitor with an IC50 value of 0.56 μM. It effectively increases interferon-gamma (INF-γ) levels and enhances immune activity by modulating T cell activation. ZM522 holds potential for research in immunology and anti-cancer fields.

CD73

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10-14 weeks

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GMPCP trisodium

GpCp trisodium

T211604

GMPCP (GpCp) trisodium (Compound 7 trisodium) is a guanine derivative and CD73 inhibitor, with Ki values of 1110 nM for rat soluble CD73 and 410 nM for human soluble CD73. This compound is applicable in cancer research.

CD73

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Enpp-1/3-IN-1

T212211

Enpp-1/3-IN-1 (Compound 5j) serves as an inhibitor for ENPP1 and ENPP3, with IC50 values of 0.59 μM for h-ENPP1 and 0.62 μM for h-ENPP3, respectively. This compound also inhibits e5′NT (CD73) and TNAP, exhibiting IC50 values of 0.89 μM for h-e5′NT, 5.12 μM for r-e5′NT, and 1.68 μM for h-TNAP. Enpp-1/3-IN-1 is applicable in cancer research.

CD73 PDE Phosphatase

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PSB-0963

T2117961213268-73-5

PSB-0963 is a selective competitive extracellular 5'-nucleotidase (eN/CD73) inhibitor with a Ki value of 150 nM for rat extracellular 5'-nucleotidase. It exhibits greater selectivity compared to other extracellular nucleotidases (NTPDases 1-3) and P2Y receptors. PSB-0963 is applicable in cancer research.

CD73

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10-14 weeks

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Uprevstobart

T9901A-15372762201-85-2

Uprevstobart is a humanized IgG1κ monoclonal antibody that targets NT5E. Its isotype control product is HumanIgG1kappa, Isotype Control.

CD73

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JAB-BX102

T9901A-1071

JAB-BX102 is a human monoclonal antibody (mAb) that targets NT5E/CD73. It is applicable in research studies involving breast cancer, pancreatic cancer, prostate cancer, and other cancers.

CD73