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Immunology/Inflammation

Aryl Hydrocarbon Receptor

Immunology/Inflammation related

NOD-like Receptor (NLR)

Prostaglandin Receptor

Reactive Oxygen Species

Thrombopoietin Receptor

CD73

5′-nucleotidase (5′-NT), also known CD73 (cluster of differentiation 73), is an enzyme that in humans is encoded by the NT5E gene. CD73 commonly serves to convert AMP to adenosine. NT5E (CD73) is a surface enzyme which is expressed on multiple cells. This enzyme mediates the gradual hydrolysis of the autocrine and paracrine danger signals of ATP and ADP to anti-inflammatory adenosine. Immune suppression mediated by adenosinergic pathways is very important for maintaining immune system homeostasis.

Filter HomeSignaling PathwaysImmunology/InflammationCD73

Oleclumab

T766951803176-05-7

Oleclumab (MEDI9447) is a human anti-CD73 monoclonal antibody with anticancer activity that inhibits the extracellular enzyme CD73 nucleic acid exonuclease activity, inhibits the adenosine pathway, and can be used for the study of metastatic desmoplasia-resistant prostate cancer.

$479

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AB-680

T102162105904-82-1

AB-680, a highly potent, reversible, and selective inhibitor of CD73 (an ectonucleotidase, Ki: 4.9 pM for hCD73) with anti-tumor activity, displays >10,000-fold selectivity over related ectonucleotidases CD39.

$115

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MethADP

T120083768-14-7In house

MethADP (Adenosine 5'-(α,β-methylene)diphosphate) is a specific CD73 inhibitor that inhibits the enzyme ecto-5′-nucleotidase (ecto), which has been used in the study of neurological and cardiovascular diseases.

$198

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CD73-IN-3

T88752375815-63-5

CD73-IN-3 (LY-3475070) is a potent and selective CD73 inhibitor with an IC50 of 28 nM, and its use alone or in combination with pembrolizumab is currently being tested in patients with advanced cancer.

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CD73-IN-4

T92102216764-29-1

CD73-IN-4 is a potent and selective methylenephosphonic acid CD73 inhibitor.

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CD73-IN-1

T107212132396-40-6

CD73-IN-1 is a CD73 inhibitor with anticancer activity.

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PSB-12379 ditriethylamine salt

T12569L In house

PSB-12379 ditriethylamine salt, a nucleotide analogue, is a potent Ecto-5'-Nucleotidase (CD73) inhibitor with Kis of 9.03 nM (rat) and 2.21 nM (human).

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Mupadolimab

T767352451856-97-4

Mupadolimab (CPI-006) is a humanized FC-γR binding deficient IgG1 anti-CD73 antibody with potential anticancer activity and activation of CD73POS B cells.

$222

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CD73-IN-5

T400332412019-99-7In house

CD73-IN-5 is a highly potent and selective small molecule inhibitor of CD73, demonstrating non-nucleotide characteristics. It exerts its inhibitory effects with a remarkable IC50 value of 19 nM.

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Dresbuxelimab

T806032550560-20-6

Dresbuxelimab (AK-119), an IgG-κ monoclonal antibody, selectively targets CD73 and is commonly produced using a Chinese Hamster Ovary (CHO) cell expression system [1].

$166

2-4 weeks

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CD73-IN-7

T605992763709-14-2

CD73-IN-7 is a potent CD73 inhibitor used for preparing medications for tumor-related diseases. CD73 catalyzes the production of adenosine from extracellular 5'-phosphate adenosine (5'-AMP), inducing immunosuppressive effects and promoting tumor proliferation and or metastasis [1].

$1,520

10-14 weeks

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CD73-IN-12

T61118

CD73-IN-12 is a highly effective CD73 inhibitor that displays strong potential in tumor suppression. CD73, an enzyme intricately linked to tumor development, angiogenesis, and metastasis, is significantly inhibited by CD73-IN-12. This compound holds promise in the formulation of therapeutic medications targeting tumor-related diseases[1].

$1,520

10-14 weeks

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CD73-IN-8

T610902763710-08-1

CD73-IN-8, a potent CD73 inhibitor, prevents the catalytic activity of CD73, an enzyme responsible for converting extracellular 5'-phosphate adenosine (5'-AMP) to adenosine. Adenosine, once produced, can induce immunosuppressive effects and facilitate tumor proliferation and or metastasis. Therefore, CD73-IN-8 holds promise in the development of therapeutic interventions for tumor-related diseases[1].

$2,140

6-8 weeks

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PSB-12379 disodium

T73628

PSB-12379 disodium is a nucleotide analogue acting as a potent inhibitor of Ecto-5'-Nucleotidase (CD73), demonstrating inhibitory constants (Ki) of 9.03 nM in rats and 2.21 nM in humans [1] [2].

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ZM522

T2033411454575-38-2

ZM522 is a CD73 inhibitor with an IC50 value of 0.56 μM. It effectively increases interferon-gamma (INF-γ) levels and enhances immune activity by modulating T cell activation. ZM522 holds potential for research in immunology and anti-cancer fields.

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10-14 weeks

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JAB-BX102

T9901A-1071

JAB-BX102 is a human monoclonal antibody (mAb) that targets NT5E/CD73. It is applicable in research studies involving breast cancer, pancreatic cancer, prostate cancer, and other cancers.

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PSB-12379

T125691802226-78-3

PSB-12379 is a potent inhibitor of Ecto-5'-Nucleotidase (CD73)(Kis of 9.03 nM (rat) and 2.21 nM (human)).

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CD73-IN-10

T610002766565-91-5

CD73-IN-10 can be used in preparing tumor-related diseases medicament. CD73-IN-10 is a potent CD73 inhibitor that can catalyze the adenosine production from extracellular 5'-phosphate adenosine (5'-AMP). Adenosine induces immunosuppression and can promote tumor proliferation and or metastasis [1].

$2,140

8-10 weeks

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CD73-IN-9

T608442766565-88-0

CD73-IN-9, a potent CD73 inhibitor, is used in preparing medication for tumor-related diseases. CD73 catalyzes the production of adenosine from extracellular 5'-phosphate adenosine (5'-AMP), which can induce immunosuppressive effects and promote tumor proliferation and or metastasis [1].

$2,140

6-8 weeks

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CD73-IN-6

T616912757808-96-9

CD73-IN-6, serves as a potent inhibitor of CD73. This compound finds utility in cancer research [1].

$1,520

8-10 weeks

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AB-680 ammonium

T73886

AB-680 ammonium is a potent, reversible, and selective CD73 inhibitor (an ecto-nucleotidase), demonstrating a K i of 4.9 pM against hCD73 and exhibiting more than 10,000-fold selectivity over the related ecto-nucleotidase CD39, along with anti-tumor activity [1].

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PSB-24000

T206762

PSB-24000 (Compound 27) is a selective ecto-5'-nucleotidase (CD73) inhibitor with a Ki value of 563 nM for inhibiting human CD73, and a Ki of 481 nM in membrane-bound CD73 in triple-negative breast cancer cells. It disrupts CD73’s recognition and action on substrate AMP, preventing AMP-induced immunosuppressive and pro-cancer adenosine production. PSB-24000 is promising for cancer research.

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BMS-986179

T9901A-1050

BMS-986179 is a human monoclonal antibody targeting NT5E/CD73. It inhibits CD73 enzymatic activity both in tumor vasculature and tumor cells. BMS-986179 is applicable for research in advanced solid tumors.

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IPH5301

T9901A-1082

IPH5301 is a human IgG1 monoclonal antibody (mAb) that targets NT5E/CD73. It features a functionally silenced Fc domain and specifically inhibits the enzymatic activity of both soluble and membrane-bound CD73, thereby restoring the proliferation of immune T cells. IPH5301 is applicable for research in anti-tumor immunotherapy. Recommended isotype control: HumanIgG1kappa, Isotype Control.

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