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Varisacumab
(Synonyms: R 84 (antibody), GNR-011) Copy Product Info
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Synonyms: R 84 (antibody), GNR-011
Catalog No. T80877 Copy Product Info
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Varisacumab (R 84) is a sophisticated human recombinant monoclonal antibody target Vascular Endothelial Growth Factor A (VEGFA), thereby effectively neutralizing its interaction with both VEGFR1 and VEGFR2 receptors. Varisacumab (R 84) has demonstrated anti-angiogenic properties in preclinical models and is extensively utilized for research involving malignancy and microvascular complications of diabetes.
Cas No. 1610010-60-0
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $280 | 4-6 weeks | 4-6 weeks | |
| 5 mg | $839 | 4-6 weeks | 4-6 weeks | |
| 10 mg | $1,330 | 4-6 weeks | 4-6 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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Product Introduction
Bioactivity
Related Conjugates and Formulations
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Chemical Properties
Antibody Information
Storage & Solubility Information
| Description | Varisacumab (R 84) is a sophisticated human recombinant monoclonal antibody target Vascular Endothelial Growth Factor A (VEGFA), thereby effectively neutralizing its interaction with both VEGFR1 and VEGFR2 receptors. Varisacumab (R 84) has demonstrated anti-angiogenic properties in preclinical models and is extensively utilized for research involving malignancy and microvascular complications of diabetes. |
| Targets & IC50 | VEGFA:< 7 nM (Kd) |
| In vitro | In binding assays with human VEGF165, Varisacumab (r84) exhibited high affinity with an EC50 of 0.288 nM and inhibited VEGF-induced tube formation in HUVEC models [1]. |
| In vivo | In human breast cancer xenograft models, systemic administration of Varisacumab (r84) significantly reduced tumor volume and microvascular density [1]. |
| Synonyms | R 84 (antibody), GNR-011 |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | VEGF-A |
| Cas No. | 1610010-60-0 |
| Isotype | IgG1 |
| Storage | Store at low temperature Store at -20°C Shipping with blue ice/Shipping at ambient temperature. |
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Related Tags: Varisacumab chemical structure | Varisacumab in vivo | Varisacumab in vitro
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