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Erythromycin A enol ether
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Catalog No. T21572Cas No. 33396-29-1
Erythromycin A enol ether is a degradation product of Erythromycin A which is a macrolide antibiotic.
Erythromycin A enol ether
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Purity: 99.94%
Catalog No. T21572Cas No. 33396-29-1
Erythromycin A enol ether is a degradation product of Erythromycin A which is a macrolide antibiotic.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $40 | In Stock | In Stock | |
| 2 mg | $65 | In Stock | In Stock | |
| 5 mg | $131 | In Stock | In Stock | |
| 10 mg | $213 | In Stock | In Stock | |
| 25 mg | $330 | In Stock | In Stock | |
| 50 mg | $471 | In Stock | In Stock | |
| 100 mg | $637 | - | In Stock | |
| 200 mg | $896 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
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Purity:99.94%
Appearance:Solid
Color:White
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Product Introduction
Erythromycin A enol ether AI Summary
Erythromycin A enol ether exhibits antibacterial activity against Staphylococcus aureus, Bacillus subtilis, and Bacillus cereus with MIC values of 50.0 µg/mL, 25.0 µg/mL, and 25.0 µg/mL respectively, but limited activity against Escherichia coli and Klebsiella pneumoniae with MIC values greater than 100.0 µg/mL. It has high affinity for the motilin receptor (IC50 = 3.388 nM), which significantly decreases in acidic conditions (IC50 = 223.87 nM). It shows smooth muscle contractile activity with an EC50 value of 41.69 nM in vitro and a motor index of 1.0 µg/kg in vivo. Its prokinetic activity is evident with a pED50 of 8.4 in isolated rabbit duodenum and it has 2.55 times the relative activity of erythromycin A. In cellular assays, 77714 demonstrates variable effects on growth rates across different cell lines, suggesting cell-type-specific bioactivities. Additionally, it affects thermal stability in various protein domains with Delta TM values ranging from -2.14°C to 0.87°C, indicating interaction with protein function. In GPCR beta-arrestin recruitment assays, Erythromycin A enol ether shows both inhibitory and stimulatory effects on multiple targets, modulating GPCR signaling pathways. It also exhibits gastrointestinal motor stimulating activity in dogs at an activity level of 10.0, based on the 2 x 2 points parallel line assay..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Erythromycin A enol ether is a degradation product of Erythromycin A which is a macrolide antibiotic. |
| Molecular Weight | 715.91 |
| Formula | C37H65NO12 |
| Cas No. | 33396-29-1 |
| Smiles | [H][C@@]1(C[C@@](C)(OC)[C@@H](O)[C@H](C)O1)O[C@H]1[C@H](C)[C@@H](O[C@]2([H])O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@]2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]1C |
| Relative Density. | 1.2g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO: Slightly soluble  |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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