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LE 28
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Catalog No. T81945Cas No. 1416080-97-1
LE 28 is a selective, activity-dependent probe for legumain that fluoresces exclusively upon binding to the active enzyme. It is applicable in research on cancers and inflammatory diseases [1].
LE 28
😃Good
Catalog No. T81945Cas No. 1416080-97-1
LE 28 is a selective, activity-dependent probe for legumain that fluoresces exclusively upon binding to the active enzyme. It is applicable in research on cancers and inflammatory diseases [1].
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | LE 28 is a selective, activity-dependent probe for legumain that fluoresces exclusively upon binding to the active enzyme. It is applicable in research on cancers and inflammatory diseases [1]. |
| In vitro | LE 28 at concentrations ranging from 0 to 5 μM, when administered for 1 hour, can be detected in RAW cell lysates through cleavage and subsequent fluorescent SDS-PAGE tagging of legumain [1]. |
| In vivo | LE 28 (2 mg/kg, i.v.) induces a specific signal in mouse kidneys [1]. In the HCT-116 xenograft tumor model, the signal appears around the tumor at 30 minutes post-administration and reaches peak signal-to-noise ratio between the tumor and normal tissue at 7 hours [1]. |
| Molecular Weight | 1909.22 |
| Formula | C102H111N10O21S3 |
| Cas No. | 1416080-97-1 |
| Smiles | S(=O)(=O)(C1=C(C=2C3=C([O+]=C4C2C=CC(=C4)N5C=6C(CC5)=CC=CC6)C=C(C=C3)N7C=8C(CC7)=CC=CC8)C=CC=C1)N9CCC(C(NCCCNC(=O)C%10=CC(C)=C(C(OCC([C@@H](NC(=O)[C@H]%11N(C([C@@H](NC(CCCCC[N+]=%12C=%13C(C(C)(C)C%12C=CC=CC=C%14N(CC)C=%15C(C%14(C)C)=CC(S(=O)(=O)O)=CC%15)=CC(S(=O)(=O)[O-])=CC%13)=O)CCC(O)=O)=O)CCC%11)CC(O)=O)=O)=O)C(C)=C%10)=O)CC9 |
Storage & Solubility Information
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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