keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LE 28 is a selective, activity-dependent probe for legumain that fluoresces exclusively upon binding to the active enzyme. It is applicable in research on cancers and inflammatory diseases [1].
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5 mg | Inquiry | Inquiry | |
50 mg | Inquiry | Inquiry |
Description | LE 28 is a selective, activity-dependent probe for legumain that fluoresces exclusively upon binding to the active enzyme. It is applicable in research on cancers and inflammatory diseases [1]. |
In vitro | LE 28 at concentrations ranging from 0 to 5 μM, when administered for 1 hour, can be detected in RAW cell lysates through cleavage and subsequent fluorescent SDS-PAGE tagging of legumain [1]. |
In vivo | LE 28 (2 mg/kg, i.v.) generates a specific signal in mouse kidneys [1]. In the HCT-116 xenograft tumor model, the signal is detectable around the tumor at 30 minutes post-administration, and at 7 hours, the signal-to-noise ratio between the tumor and normal tissue peaks [1]. |
Molecular Weight | 1909.22 |
Formula | C102H111N10O21S3 |
CAS No. | 1416080-97-1 |
keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
LE 28 1416080-97-1 inhibitor inhibit