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LSN3353871

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Catalog No. T88199Cas No. 2565657-20-5

LSN3353871 is a highly potent and orally available lipoprotein a [Lp(a)] inhibitor (IC50 = 1.69 µM) that binds to Kringle IV (KIV) to inhibit Lp(a) formation and assembly, making it suitable for studying cardiovascular diseases.

LSN3353871

LSN3353871

😃Good
Purity: 99.84%
Catalog No. T88199Cas No. 2565657-20-5
LSN3353871 is a highly potent and orally available lipoprotein a [Lp(a)] inhibitor (IC50 = 1.69 µM) that binds to Kringle IV (KIV) to inhibit Lp(a) formation and assembly, making it suitable for studying cardiovascular diseases.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$100-In Stock
5 mg$247-In Stock
10 mg$396-In Stock
25 mg$828-In Stock
50 mg$1,320-In Stock
100 mg$1,980-In Stock
200 mg$2,790-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:99.84%
Appearance:Solid
Color:White
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Product Introduction

Bioactivity
Description
LSN3353871 is a highly potent and orally available lipoprotein a [Lp(a)] inhibitor (IC50 = 1.69 µM) that binds to Kringle IV (KIV) to inhibit Lp(a) formation and assembly, making it suitable for studying cardiovascular diseases.
Chemical Properties
Molecular Weight255.74
FormulaC13H18ClNO2
Cas No.2565657-20-5
Smiles[C@@H](CC1=CC=CC=C1)(C(O)=O)[C@]2(CCNC2)[H].Cl
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 120 mg/mL (469.23 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.9102 mL19.5511 mL39.1022 mL195.5111 mL
5 mM0.7820 mL3.9102 mL7.8204 mL39.1022 mL
10 mM0.3910 mL1.9551 mL3.9102 mL19.5511 mL
20 mM0.1955 mL0.9776 mL1.9551 mL9.7756 mL
50 mM0.0782 mL0.3910 mL0.7820 mL3.9102 mL
100 mM0.0391 mL0.1955 mL0.3910 mL1.9551 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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