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Lys-SMCC-DM1

Name: Lys-SMCC-DM1
Brand: TargetMol
SKU: T11917
Price: 1480 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11917Cas No. 1281816-04-3

Alias Lys-Nε-MCC-DM1

Lys-SMCC-DM1 (Lys-Nε-MCC-DM1) is an antibody-drug conjugate (ADC) targeting human epidermal growth factor receptor 2 (HER2). It contains the microtubule polymerization inhibitor DM1 as the active metabolite, which inhibits microtubule polymerization. It is commonly used in breast cancer research.

Lys-SMCC-DM1

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Catalog No. T11917Alias Lys-Nε-MCC-DM1Cas No. 1281816-04-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$289	-	In Stock
5 mg	$691	-	In Stock
10 mg	$997	-	In Stock
25 mg	$1,480	-	In Stock
50 mg	Preferential	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$1,190	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:≥98%

Appearance:Solid

Color:White

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COA HNMR

Product Introduction

Bioactivity

Description	Lys-SMCC-DM1 (Lys-Nε-MCC-DM1) is an antibody-drug conjugate (ADC) targeting human epidermal growth factor receptor 2 (HER2). It contains the microtubule polymerization inhibitor DM1 as the active metabolite, which inhibits microtubule polymerization. It is commonly used in breast cancer research.
In vitro	METHODS: Lys-SMCC-DM1, DXd (1), and DXd (2) were simultaneously subjected to parallel artificial membrane permeability assay (PAMPA) using the Lys-SMCC-DM1 Freedom EVO200 system. RESULTS: Lys-SMCC-DM1 has low permeability. [1] METHODS: MDCKII/SLC46A3 dC cells were treated with Lys-SMCC-DM1 (5 µM) for 30 min, and a cellular uptake assay was performed to verify whether SLC46A3 directly transported Lys-SMCC-DM1. RESULTS: SLC46A3 directly recognized and transported Lys-SMCC-DM1 and mediated the cytotoxic effects of T-DM1. [2]
Synonyms	Lys-Nε-MCC-DM1

Chemical Properties

Molecular Weight	1103.71
Formula	C₅₃H₇₅ClN₆O₁₅S
Cas No.	1281816-04-3
Smiles	C[C@]12[C@@](O1)([C@H](C)[C@@]3(C[C@](O)([C@H](OC)/C=C/C=C(\C)/CC4=CC(N(C)C(=O)C[C@@H]2OC([C@@H](N(C(CCS[C@@H]5C(=O)N(C[C@@H]6CC[C@@H](C(NCCCC[C@@H](C(O)=O)N)=O)CC6)C(=O)C5)=O)C)C)=O)=C(Cl)C(OC)=C4)NC(=O)O3)[H])[H]
Relative Density.	1.36 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (54.36 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (1.81 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.9060 mL	4.5302 mL	9.0604 mL	45.3018 mL
5 mM	0.1812 mL	0.9060 mL	1.8121 mL	9.0604 mL
10 mM	0.0906 mL	0.4530 mL	0.9060 mL	4.5302 mL
20 mM	0.0453 mL	0.2265 mL	0.4530 mL	2.2651 mL
50 mM	0.0181 mL	0.0906 mL	0.1812 mL	0.9060 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc