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Lys-SMCC-DM1

Name: Lys-SMCC-DM1
Brand: TargetMol
SKU: T11917
Price: 1480 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11917Cas No. 1281816-04-3

Alias Lys-Nε-MCC-DM1

Lys-SMCC-DM1 (Lys-Nε-MCC-DM1) is an antibody-drug conjugate (ADC) targeting human epidermal growth factor receptor 2 (HER2). It contains the microtubule polymerization inhibitor DM1 as the active metabolite, which inhibits microtubule polymerization. It is commonly used in breast cancer research.

Lys-SMCC-DM1

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Catalog No. T11917Alias Lys-Nε-MCC-DM1Cas No. 1281816-04-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$289	-	In Stock
5 mg	$691	-	In Stock
10 mg	$997	-	In Stock
25 mg	$1,480	-	In Stock
50 mg	Preferential	Backorder	Backorder
1 mL x 10 mM (in DMSO)	$1,190	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:≥98%

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COA HNMR

Product Introduction

Bioactivity

Description	Lys-SMCC-DM1 (Lys-Nε-MCC-DM1) is an antibody-drug conjugate (ADC) targeting human epidermal growth factor receptor 2 (HER2). It contains the microtubule polymerization inhibitor DM1 as the active metabolite, which inhibits microtubule polymerization. It is commonly used in breast cancer research.
In vitro	METHODS: Lys-SMCC-DM1, DXd (1), and DXd (2) were simultaneously subjected to parallel artificial membrane permeability assay (PAMPA) using the Lys-SMCC-DM1 Freedom EVO200 system. RESULTS: Lys-SMCC-DM1 has low permeability. [1] METHODS: MDCKII/SLC46A3 dC cells were treated with Lys-SMCC-DM1 (5 µM) for 30 min, and a cellular uptake assay was performed to verify whether SLC46A3 directly transported Lys-SMCC-DM1. RESULTS: SLC46A3 directly recognized and transported Lys-SMCC-DM1 and mediated the cytotoxic effects of T-DM1. [2]
Synonyms	Lys-Nε-MCC-DM1

Chemical Properties

Molecular Weight	1103.71
Formula	C₅₃H₇₅ClN₆O₁₅S
Cas No.	1281816-04-3
Smiles	C[C@]12[C@@](O1)([C@H](C)[C@@]3(C[C@](O)([C@H](OC)/C=C/C=C(\C)/CC4=CC(N(C)C(=O)C[C@@H]2OC([C@@H](N(C(CCS[C@@H]5C(=O)N(C[C@@H]6CC[C@@H](C(NCCCC[C@@H](C(O)=O)N)=O)CC6)C(=O)C5)=O)C)C)=O)=C(Cl)C(OC)=C4)NC(=O)O3)[H])[H]
Relative Density.	1.36 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (54.36 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (1.81 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.9060 mL	4.5302 mL	9.0604 mL	45.3018 mL
5 mM	0.1812 mL	0.9060 mL	1.8121 mL	9.0604 mL
10 mM	0.0906 mL	0.4530 mL	0.9060 mL	4.5302 mL
20 mM	0.0453 mL	0.2265 mL	0.4530 mL	2.2651 mL
50 mM	0.0181 mL	0.0906 mL	0.1812 mL	0.9060 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc