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SJ6986

Name: SJ6986
Brand: TargetMol
SKU: T41257
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T41257Cas No. 2765625-93-0

SJ6986 is a potent, selective, and orally active GSPT1/2 degrader, effectively degrading GSPT1 with a DC50 of 2.1 nM (D max 99%) [1].

SJ6986

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Purity: 99.73%

Catalog No. T41257Cas No. 2765625-93-0

SJ6986 is a potent, selective, and orally active GSPT1/2 degrader, effectively degrading GSPT1 with a DC50 of 2.1 nM (D max 99%) [1].

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$48	In Stock	In Stock
10 mg	$78	In Stock	In Stock
25 mg	$143	In Stock	In Stock
50 mg	$257	In Stock	In Stock
100 mg	$397	-	In Stock
500 mg	$945	-	In Stock
1 mL x 10 mM (in DMSO)	$54	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.73%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	SJ6986 is a potent, selective, and orally active GSPT1/2 degrader, effectively degrading GSPT1 with a DC50 of 2.1 nM (D max 99%) [1].
In vitro	SJ6986 demonstrates potency with EC50 values at 1.5 nM, 0.4 nM, 726 nM, 336 nM, and 3583 nM in the MV4-11, MHH-CALL-4, MB002, MB004, and HD-MB03 cell lines respectively [1]. In MV4-11 cells, under conditions of a 0-100 μM concentration range and a 3-day incubation, an EC50 of 1.5 nM was observed, indicating significant inhibition of cell proliferation [1]. Additionally, Western Blot analysis in the same cell line, with a concentration range of 0-10 μM over 4 and 24 hours, revealed a dose- and time-dependent reduction in GSPT1 protein levels, further confirming the compound's efficacy [1].
In vivo	SJ6986 shows t 1/2 of 3.44 h by intravenous injection of 3 mg/kg and t max of 0.25 h by oral administration (%F = 84) of 10 mg/kg in CD1 mice [1].

Chemical Properties

Molecular Weight	497.4
Formula	C₂₀H₁₄F₃N₃O₇S
Cas No.	2765625-93-0
Smiles	O=C1N(C(=O)C=2C1=CC(NS(=O)(=O)C3=C(OC(F)(F)F)C=CC=C3)=CC2)C4C(=O)NC(=O)CC4

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (502.61 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: 2.5 mg/mL (5.03 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0105 mL	10.0523 mL	20.1045 mL	100.5227 mL
5 mM	0.4021 mL	2.0105 mL	4.0209 mL	20.1045 mL
10 mM	0.2010 mL	1.0052 mL	2.0105 mL	10.0523 mL
20 mM	0.1005 mL	0.5026 mL	1.0052 mL	5.0261 mL
50 mM	0.0402 mL	0.2010 mL	0.4021 mL	2.0105 mL
100 mM	0.0201 mL	0.1005 mL	0.2010 mL	1.0052 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc