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SJ6986

Name: SJ6986
Brand: TargetMol
SKU: T41257
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T41257Cas No. 2765625-93-0

SJ6986 is a potent, selective, and orally active GSPT1/2 degrader, effectively degrading GSPT1 with a DC50 of 2.1 nM (D max 99%) [1].

SJ6986

🥰Excellent

Purity: 99.73%

Catalog No. T41257Cas No. 2765625-93-0

SJ6986 is a potent, selective, and orally active GSPT1/2 degrader, effectively degrading GSPT1 with a DC50 of 2.1 nM (D max 99%) [1].

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$48	In Stock	In Stock
10 mg	$78	In Stock	In Stock
25 mg	$143	In Stock	In Stock
50 mg	$257	In Stock	In Stock
100 mg	$397	-	In Stock
500 mg	$945	-	In Stock
1 mL x 10 mM (in DMSO)	$54	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.73%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	SJ6986 is a potent, selective, and orally active GSPT1/2 degrader, effectively degrading GSPT1 with a DC50 of 2.1 nM (D max 99%) [1].
In vitro	SJ6986 demonstrates potency with EC50 values at 1.5 nM, 0.4 nM, 726 nM, 336 nM, and 3583 nM in the MV4-11, MHH-CALL-4, MB002, MB004, and HD-MB03 cell lines respectively [1]. In MV4-11 cells, under conditions of a 0-100 μM concentration range and a 3-day incubation, an EC50 of 1.5 nM was observed, indicating significant inhibition of cell proliferation [1]. Additionally, Western Blot analysis in the same cell line, with a concentration range of 0-10 μM over 4 and 24 hours, revealed a dose- and time-dependent reduction in GSPT1 protein levels, further confirming the compound's efficacy [1].
In vivo	SJ6986 shows t 1/2 of 3.44 h by intravenous injection of 3 mg/kg and t max of 0.25 h by oral administration (%F = 84) of 10 mg/kg in CD1 mice [1].

Chemical Properties

Molecular Weight	497.4
Formula	C₂₀H₁₄F₃N₃O₇S
Cas No.	2765625-93-0
Smiles	O=C1N(C(=O)C=2C1=CC(NS(=O)(=O)C3=C(OC(F)(F)F)C=CC=C3)=CC2)C4C(=O)NC(=O)CC4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (110.57 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: 2.5 mg/mL (5.03 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0105 mL	10.0523 mL	20.1045 mL	100.5227 mL
5 mM	0.4021 mL	2.0105 mL	4.0209 mL	20.1045 mL
10 mM	0.2010 mL	1.0052 mL	2.0105 mL	10.0523 mL
20 mM	0.1005 mL	0.5026 mL	1.0052 mL	5.0261 mL
50 mM	0.0402 mL	0.2010 mL	0.4021 mL	2.0105 mL
100 mM	0.0201 mL	0.1005 mL	0.2010 mL	1.0052 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc