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GW406108X

Name: GW406108X
Brand: TargetMol
SKU: T9207
Price: 149 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9207Cas No. 1644443-92-4

Alias GW108X

GW406108X (GW108X) is a Kif15 inhibitor with an IC50 of 0.82 uM in ATPase assays. GW406108X is also an ULK1 kinase inhibitor with pIC50 values of 6.37 (427 nM) and block autophagic flux.

GW406108X

🥰Excellent

Purity: 98%

Catalog No. T9207Alias GW108XCas No. 1644443-92-4

GW406108X (GW108X) is a Kif15 inhibitor with an IC50 of 0.82 uM in ATPase assays. GW406108X is also an ULK1 kinase inhibitor with pIC50 values of 6.37 (427 nM) and block autophagic flux.

Pack Size	Price	Availability	Quantity
2 mg	$149	In Stock

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Purity:98%

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Product Introduction

Bioactivity

Description	GW406108X (GW108X) is a Kif15 inhibitor with an IC50 of 0.82 uM in ATPase assays. GW406108X is also an ULK1 kinase inhibitor with pIC50 values of 6.37 (427 nM) and block autophagic flux.
Targets&IC50	KIF15:0.82 μM, ULK1:PIC50=6.37
In vitro	GW406108X were acting upon ULK1 and autophagy without affecting mTOR or AMPK activity as shown by monitoring ULK1 pS758 (mTOR site) or pS556 (AMPK site) levels[1].
Synonyms	GW108X

Chemical Properties

Molecular Weight	400.21
Formula	C₂₀H₁₁Cl₂NO₄
Cas No.	1644443-92-4
Smiles	Oc1c(Cl)cc(\C=C2/C(=O)Nc3ccc(cc23)C(=O)c2ccco2)cc1Cl
Relative Density.	1.527 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (112.44 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4987 mL	12.4934 mL	24.9869 mL	124.9344 mL
5 mM	0.4997 mL	2.4987 mL	4.9974 mL	24.9869 mL
10 mM	0.2499 mL	1.2493 mL	2.4987 mL	12.4934 mL
20 mM	0.1249 mL	0.6247 mL	1.2493 mL	6.2467 mL
50 mM	0.0500 mL	0.2499 mL	0.4997 mL	2.4987 mL
100 mM	0.0250 mL	0.1249 mL	0.2499 mL	1.2493 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc