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Mardepodect hydrochloride (Alias: PF-2545920 HCl, PF-02545920 HCl, MP-10 HCl, Mardepodect HCl)

Name: Mardepodect hydrochloride
Brand: TargetMol
SKU: T62356
Price: 199 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T62356 Copy Product Info

Purity: 95.1%

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Mardepodect hydrochloride (Mardepodect HCl) is an orally active, selective and potent inhibitor of PDE10A that crosses the blood-brain barrier (IC50: 0.37 nM).Mardepodect hydrochloride up-regulates the expression of proteins encoding specific growth and transcription factors, cell signalling molecules and cell surface proteins. Mardepodect hydrochloride upregulates genes encoding specific growth factors, transcription factors, cell signalling molecules, and cell surface proteins, while downregulating a broad spectrum of cell cycle and apoptosis-related genes.

Mardepodect hydrochloride

Copy Product Info

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Catalog No. T62356

Alias PF-2545920 HCl, PF-02545920 HCl, MP-10 HCl, Mardepodect HCl

Cas No. 2070014-78-5

Pack Size	Price	USA Stock	Global Stock	Quantity
5 mg	$199	-	In Stock
1 mL x 10 mM (in DMSO)	$249	-	In Stock

In stock · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:95.1%

Appearance:Solid

Color:White

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COA LCMS

Product Introduction

Bioactivity

Description	Mardepodect hydrochloride (Mardepodect HCl) is an orally active, selective and potent inhibitor of PDE10A that crosses the blood-brain barrier (IC50: 0.37 nM).Mardepodect hydrochloride up-regulates the expression of proteins encoding specific growth and transcription factors, cell signalling molecules and cell surface proteins. Mardepodect hydrochloride upregulates genes encoding specific growth factors, transcription factors, cell signalling molecules, and cell surface proteins, while downregulating a broad spectrum of cell cycle and apoptosis-related genes.
Targets&IC50	PDE10A:0.37 nM
In vivo	Injecting Mardepodect hydrochloride (PF-2545920) into mice leads to a dose-dependent increase in striatal cyclic guanosine monophosphate (cGMP). Its median effective dose (ED50) is 1 mg/kg [2].
Synonyms	PF-2545920 HCl, PF-02545920 HCl, MP-10 HCl, Mardepodect HCl

Chemical Properties

Molecular Weight	428.91
Formula	C₂₅H₂₁ClN₄O
Cas No.	2070014-78-5
Smiles	Cl.Cn1cc(c(n1)-c1ccc(OCc2ccc3ccccc3n2)cc1)-c1ccncc1

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20 mg/mL (46.63 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.5 mg/mL (5.83 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3315 mL	11.6575 mL	23.3149 mL	116.5746 mL
5 mM	0.4663 mL	2.3315 mL	4.6630 mL	23.3149 mL
10 mM	0.2331 mL	1.1657 mL	2.3315 mL	11.6575 mL
20 mM	0.1166 mL	0.5829 mL	1.1657 mL	5.8287 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc