keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Mardepodect hydrochloride (Mardepodect HCl) is an orally active, selective and potent inhibitor of PDE10A that crosses the blood-brain barrier (IC50: 0.37 nM).Mardepodect hydrochloride up-regulates the expression of proteins encoding specific growth and transcription factors, cell signalling molecules and cell surface proteins. Mardepodect hydrochloride upregulates genes encoding specific growth factors, transcription factors, cell signalling molecules, and cell surface proteins, while downregulating a broad spectrum of cell cycle and apoptosis-related genes.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 78.00 | |
5 mg | In stock | $ 143.00 | |
10 mg | In stock | $ 284.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 170.00 |
Description | Mardepodect hydrochloride (Mardepodect HCl) is an orally active, selective and potent inhibitor of PDE10A that crosses the blood-brain barrier (IC50: 0.37 nM).Mardepodect hydrochloride up-regulates the expression of proteins encoding specific growth and transcription factors, cell signalling molecules and cell surface proteins. Mardepodect hydrochloride upregulates genes encoding specific growth factors, transcription factors, cell signalling molecules, and cell surface proteins, while downregulating a broad spectrum of cell cycle and apoptosis-related genes. |
Targets&IC50 | PDE10A:0.37 nM |
In vivo | Injecting Mardepodect hydrochloride (PF-2545920) into mice leads to a dose-dependent increase in striatal cyclic guanosine monophosphate (cGMP). Its median effective dose (ED50) is 1 mg/kg [2]. |
Synonyms | PF-2545920 HCl, Mardepodect HCl, MP-10 HCl, PF-02545920 HCl |
Molecular Weight | 428.91 |
Formula | C25H21ClN4O |
CAS No. | 2070014-78-5 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 20 mg/mL (46.62 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Mardepodect hydrochloride 2070014-78-5 Apoptosis Metabolism PDE PF-2545920 HCl Mardepodect HCl MP-10 HCl PF-02545920 HCl inhibitor inhibit