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CP-640186

Name: CP-640186
Brand: TargetMol
SKU: T1889
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1889Cas No. 591778-68-6

Alias CP-640,186, CP 640186

CP-640186 is an isozyme-nonselective Acetyl-CoA carboxylase (ACCase) inhibitor. The IC50s of CP-640186(CP 640186) is 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively.

CP-640186

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Purity: 99.87%

Catalog No. T1889Alias CP-640,186, CP 640186Cas No. 591778-68-6

CP-640186 is an isozyme-nonselective Acetyl-CoA carboxylase (ACCase) inhibitor. The IC50s of CP-640186(CP 640186) is 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$32	In Stock	-
5 mg	$73	In Stock	-
10 mg	$118	In Stock	-
25 mg	$247	In Stock	-
50 mg	$353	In Stock	-
100 mg	$526	In Stock	-
1 mL x 10 mM (in DMSO)	$78	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.87%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

CP-640186 AI Summary

CP-640186 exhibits potent inhibitory activity against acetyl-CoA carboxylase enzymes, inhibiting rat ACC2 with an IC50 of 61.0 nM, rat ACC1 with an IC50 of 53.0 nM, human recombinant ACC2 with IC50 values of 34.0 nM and 38.0 nM, and human recombinant ACC1 with IC50 values of 410.0 nM and 550.0 nM. It demonstrates a strong selectivity for human ACC2 over human ACC1 with an IC50 ratio of 11.0. In rat skeletal muscle, it inhibits acetyl-CoA carboxylase with an IC50 of 55.0 nM. The compound also exhibits inhibitory effects on fatty acid synthesis in HepG2 cells and shows metabolic stability in human liver microsomes. With an IC50 range from 70.0 nM to 910.0 nM across various assays, it indicates substantial potency. Additionally, in obese Zucker rats, it reduces hepatic malonyl-CoA levels significantly, showing antiobesity activity. Plasma protein binding studies show strong interaction with human plasma (PPB of 93.39%). CP-640186 also exhibits potential antiviral activity against SARS-CoV-2 and inhibitory activity on human HDAC6 enzyme..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	CP-640186 is an isozyme-nonselective Acetyl-CoA carboxylase (ACCase) inhibitor. The IC50s of CP-640186(CP 640186) is 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively.
Targets&IC50	ACC1:53 nM, ACC12:61 nM
Synonyms	CP-640,186, CP 640186

Chemical Properties

Molecular Weight	485.62
Formula	C₃₀H₃₅N₃O₃
Cas No.	591778-68-6
Smiles	O=C([C@@H]1CCCN(C1)C1CCN(CC1)C(=O)c1c2ccccc2cc2ccccc12)N1CCOCC1
Relative Density.	1.245 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (92.67 mM), Sonication is recommended.

Ethanol: Soluble

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.12 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0592 mL	10.2961 mL	20.5922 mL	102.9612 mL
5 mM	0.4118 mL	2.0592 mL	4.1184 mL	20.5922 mL
10 mM	0.2059 mL	1.0296 mL	2.0592 mL	10.2961 mL
20 mM	0.1030 mL	0.5148 mL	1.0296 mL	5.1481 mL
50 mM	0.0412 mL	0.2059 mL	0.4118 mL	2.0592 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc