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α-Solanine

Name: α-Solanine
Brand: TargetMol
SKU: TN1376
Price: 272 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN1376Cas No. 20562-02-1

Alias alpha-Solanine

α-Solanine (alpha-Solanine) is an alkaloid derived from potato with anticancer and antitumor activity, attenuating chondrocyte death by inhibiting the NF-κB pathway. α-Solanine inhibits the proliferation and migration of glioma cells but promotes apoptosis of glioma cells.

α-Solanine

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Purity: 99.37%

Catalog No. TN1376Alias alpha-SolanineCas No. 20562-02-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$68	In Stock	In Stock
5 mg	$172	In Stock	In Stock
10 mg	$272	-	In Stock
25 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$266	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.37%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	α-Solanine (alpha-Solanine) is an alkaloid derived from potato with anticancer and antitumor activity, attenuating chondrocyte death by inhibiting the NF-κB pathway. α-Solanine inhibits the proliferation and migration of glioma cells but promotes apoptosis of glioma cells.
In vitro	METHODS: α-solanine (3, 6, 9, 12 μg/μl) was used to treat PANC-1, sw1990 and MIA PaCa-2 cells for 24 h or 48 h, and the viability of cells was observed. RESULTS: After treatment with α-solanine (12 μg/μl), the cell viability was significantly decreased. At α-solanine concentrations of 3, 6, and 9 μg/μl, and treatment time of 24 h and 48 h, α-solanine did not cause cytotoxicity in the cells of each cell line. α-Solanine (3, 6 and 9 μg/μl) significantly reduced the mRNA and protein expression of VEGF in PANC-1 cells in a dose-dependent manner, while α-solanine inhibited angiogenesis by inhibiting VEGF expression.[1]
In vivo	METHODS: 1 μl/g of α-solanine was injected into the peritoneal cavity of each mouse for two weeks. The body weight of the mice and the size of their tumors were measured daily. RESULTS: α-solanine inhibited the growth of PANC-1 tumor xenografts, reducing tumor volume by 61% (P<0.05). [1]
Synonyms	alpha-Solanine

Chemical Properties

Molecular Weight	868.06
Formula	C₄₅H₇₃NO₁₅
Cas No.	20562-02-1
Smiles	C[C@@H]1[C@H]2CC[C@H](C)CN2[C@H]2C[C@H]3[C@@H]4CC=C5C[C@H](CC[C@]5(C)[C@H]4CC[C@]3(C)[C@@H]12)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H]1O[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O
Relative Density.	1.40 g/cm3 at 20℃
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (34.56 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (1.15 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1520 mL	5.7600 mL	11.5199 mL	57.5997 mL
5 mM	0.2304 mL	1.1520 mL	2.3040 mL	11.5199 mL
10 mM	0.1152 mL	0.5760 mL	1.1520 mL	5.7600 mL
20 mM	0.0576 mL	0.2880 mL	0.5760 mL	2.8800 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc