Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MEL24, an Mdm2 E3 ligase inhibitor, diminishes cell viability and enhances sensitivity to DNA-damaging agents in a p53-dependent manner, suggesting its potential for in vitro antitumor research [1].
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Description | MEL24, an Mdm2 E3 ligase inhibitor, diminishes cell viability and enhances sensitivity to DNA-damaging agents in a p53-dependent manner, suggesting its potential for in vitro antitumor research [1]. |
In vitro | MEL24 targets 293T cells with an ED50 of 9.2 μM [1]. At a concentration of 15 μM for 6 hours, MEL24 elevates the levels of Mdm2, p53, and MdmX, activating p53, and inhibiting the degradation of endogenous MdmX in HCT116 cells (p53 wild-type) [1]. |
Molecular Weight | 326.35 |
Formula | C17H18N4O3 |
CAS No. | 642072-48-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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MEL24 642072-48-8 Others inhibitor inhibit