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Tropisetron hydrochloride

Name: Tropisetron hydrochloride
Brand: TargetMol
SKU: T1173
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1173Cas No. 105826-92-4

Alias Tropisetron HCl, SDZ-ICS 930, ICS 205-930

Tropisetron hydrochloride (Tropisetron HCl) is the hydrochloride salt form of tropisetron, a selective, competitive serotonin 5-hydroxytryptamine type 3 (5-HT3) receptor antagonist, with antinauseant and antiemetic activities.

Tropisetron hydrochloride

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Purity: 99.88%

Catalog No. T1173Alias Tropisetron HCl, SDZ-ICS 930, ICS 205-930Cas No. 105826-92-4

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$48	In Stock	In Stock
25 mg	$64	In Stock	In Stock
50 mg	$81	In Stock	In Stock
100 mg	$108	In Stock	In Stock
200 mg	$162	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.88%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Tropisetron hydrochloride (Tropisetron HCl) is the hydrochloride salt form of tropisetron, a selective, competitive serotonin 5-hydroxytryptamine type 3 (5-HT3) receptor antagonist, with antinauseant and antiemetic activities.
Targets&IC50	5-HT3 receptor:70.1 ± 0.9 nM
In vivo	Tropisetron (1 mg/kg i.p.) significantly improves the deficient inhibitory processing of the P20-N40 auditory evoked potential in DBA/2 mice. [5]
Synonyms	Tropisetron HCl, SDZ-ICS 930, ICS 205-930

Chemical Properties

Molecular Weight	320.82
Formula	C₁₇H₂₁ClN₂O₂
Cas No.	105826-92-4
Smiles	Cl.CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)c1c[nH]c2ccccc12
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 6.25 mg/mL (19.48 mM), Sonication is recommended.

H2O: 50 mg/mL (155.85 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	3.1170 mL	15.5851 mL	31.1701 mL	155.8506 mL
5 mM	0.6234 mL	3.1170 mL	6.2340 mL	31.1701 mL
10 mM	0.3117 mL	1.5585 mL	3.1170 mL	15.5851 mL

H2O

	1mg	5mg	10mg	50mg
20 mM	0.1559 mL	0.7793 mL	1.5585 mL	7.7925 mL
50 mM	0.0623 mL	0.3117 mL	0.6234 mL	3.1170 mL
100 mM	0.0312 mL	0.1559 mL	0.3117 mL	1.5585 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc