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BDCRB

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Catalog No. T67887

BDCRB inhibits herpesvirus DNA maturation. BDCRB causes the HCMV terminase to skip the normal cleavage site and to continue to package DNA until a second cleavage site is encountered 30 kb further along the concatemer.

BDCRB

BDCRB

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Purity: 99.85%
Catalog No. T67887
BDCRB inhibits herpesvirus DNA maturation. BDCRB causes the HCMV terminase to skip the normal cleavage site and to continue to package DNA until a second cleavage site is encountered 30 kb further along the concatemer.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$133In StockIn Stock
5 mg$320In StockIn Stock
10 mg$480In StockIn Stock
25 mg$786In StockIn Stock
50 mg$1,080In StockIn Stock
100 mg$1,480In StockIn Stock
500 mg$2,960-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.85%
Appearance:Solid
Color:White
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Product Introduction

BDCRB AI Summary
BDCRB exhibits significant antiviral activity against human cytomegalovirus (HCMV) with an IC50 of 700.0 nM and an IC90 of 200.0 nM, indicating its effectiveness in inhibiting viral replication. It also shows moderate activity against herpes simplex virus type-1 (HSV-1) with an IC50 of 130,000.0 nM. The compound demonstrates visual cytotoxicity on human foreskin fibroblasts (HFF) cells with an IC50 of 118,000.0 nM. However, it shows limited cytotoxicity against the human oral carcinoma cell line (KB), with an IC50 greater than 100,000.0 nM. Additionally, BDCRB has demonstrated antiviral activities against other viruses such as VZV, MCMV, and RCMV, further suggesting its broad-spectrum antiviral potential. Despite its potent antiviral effects, the compound's cytotoxicity profile and selectivity index indicate potential therapeutic benefits, particularly in ganciclovir-sensitive and ganciclovir-resistant HCMV infections..
Note: Summary generated by AI. Data source: ChEMBL
Bioactivity
Description
BDCRB inhibits herpesvirus DNA maturation. BDCRB causes the HCMV terminase to skip the normal cleavage site and to continue to package DNA until a second cleavage site is encountered 30 kb further along the concatemer.
Chemical Properties
Molecular Weight398.04
FormulaC12H11BrCl2N2O4
SmilesOC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1c(Br)nc2cc(Cl)c(Cl)cc12
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 55 mg/mL (138.18 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5123 mL12.5616 mL25.1231 mL125.6155 mL
5 mM0.5025 mL2.5123 mL5.0246 mL25.1231 mL
10 mM0.2512 mL1.2562 mL2.5123 mL12.5616 mL
20 mM0.1256 mL0.6281 mL1.2562 mL6.2808 mL
50 mM0.0502 mL0.2512 mL0.5025 mL2.5123 mL
100 mM0.0251 mL0.1256 mL0.2512 mL1.2562 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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