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OSS_128167

Name: OSS_128167
Brand: TargetMol
SKU: T4328
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4328Cas No. 887686-02-4

Alias SIRT6-IN-1

OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM).

OSS_128167

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Purity: 98.6%

Catalog No. T4328Alias SIRT6-IN-1Cas No. 887686-02-4

OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$38	In Stock	In Stock
5 mg	$85	In Stock	In Stock
10 mg	$119	In Stock	In Stock
25 mg	$247	In Stock	In Stock
50 mg	$372	In Stock	In Stock
100 mg	$558	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$85	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.6%

Appearance:Solid

Color:White

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COA HNMR HPLC LCMS

Product Introduction

Bioactivity

Description	OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM).
Targets&IC50	SIRT1 (cell-free assay):1578 μM, SIRT6 (cell-free assay):89 μM, SIRT2 (cell-free assay):751 μM
In vitro	OSS-128167 increases H3K9 acetylation and GLUT-1 expression, and proves to be a selective compounds toward SIRT6.
Kinase Assay	In supernatants from cells, which are incubated in OSS_128167 (100 μM) for 18 hours,TNF-a levels are measured .
Cell Research	BxPC3 cells are stimulated with 100 μM OSS-128167 incubating 0, 2, 6, 18, 24 hours.
Synonyms	SIRT6-IN-1

Chemical Properties

Molecular Weight	366.32
Formula	C₁₉H₁₄N₂O₆
Cas No.	887686-02-4
Smiles	OC(=O)c1cc(NC(=O)c2cccc(NC(=O)c3ccco3)c2)ccc1O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 50 mg/mL (136.49 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.46 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7299 mL	13.6493 mL	27.2985 mL	136.4927 mL
5 mM	0.5460 mL	2.7299 mL	5.4597 mL	27.2985 mL
10 mM	0.2730 mL	1.3649 mL	2.7299 mL	13.6493 mL
20 mM	0.1365 mL	0.6825 mL	1.3649 mL	6.8246 mL
50 mM	0.0546 mL	0.2730 mL	0.5460 mL	2.7299 mL
100 mM	0.0273 mL	0.1365 mL	0.2730 mL	1.3649 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc