Shopping Cart

Remove All
Your shopping cart is currently empty

OSS_128167

Name: OSS_128167
Brand: TargetMol
SKU: T4328
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T4328Cas No. 887686-02-4

Alias SIRT6-IN-1

OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM).

OSS_128167

🥰Excellent

Purity: 98.6%

Catalog No. T4328Alias SIRT6-IN-1Cas No. 887686-02-4

OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM).

Pack Size	Price	Availability
1 mg	$38	In Stock
5 mg	$85	In Stock
10 mg	$119	In Stock
25 mg	$247	In Stock
50 mg	$389	In Stock
100 mg	$586	In Stock
200 mg	$836	In Stock
1 mL x 10 mM (in DMSO)	$85	In Stock

Add to Cart

Add to Quotation

Bulk & Custom

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:98.6%

Resource Download

COA LCMS HNMR HPLC

Product Introduction

Bioactivity

Description	OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM).
Targets&IC50	SIRT6 (cell-free assay):89 μM, SIRT2 (cell-free assay):751 μM, SIRT1 (cell-free assay):1578 μM
In vitro	OSS-128167 increases H3K9 acetylation and GLUT-1 expression, and proves to be a selective compounds toward SIRT6.
Kinase Assay	In supernatants from cells, which are incubated in OSS_128167 (100 μM) for 18 hours,TNF-a levels are measured .
Cell Research	BxPC3 cells are stimulated with 100 μM OSS-128167 incubating 0, 2, 6, 18, 24 hours.
Synonyms	SIRT6-IN-1

Chemical Properties

Molecular Weight	366.32
Formula	C₁₉H₁₄N₂O₆
Cas No.	887686-02-4
Smiles	OC(=O)c1cc(NC(=O)c2cccc(NC(=O)c3ccco3)c2)ccc1O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 45 mg/mL (122.84 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7299 mL	13.6493 mL	27.2985 mL	136.4927 mL
5 mM	0.5460 mL	2.7299 mL	5.4597 mL	27.2985 mL
10 mM	0.2730 mL	1.3649 mL	2.7299 mL	13.6493 mL
20 mM	0.1365 mL	0.6825 mL	1.3649 mL	6.8246 mL
50 mM	0.0546 mL	0.2730 mL	0.5460 mL	2.7299 mL
100 mM	0.0273 mL	0.1365 mL	0.2730 mL	1.3649 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc