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Direct Violet 1 (CCRIS 2413) is an agent of dye.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 g | $30 | In Stock | |
1 mL x 10 mM (in DMSO) | $45 | In Stock |
Description | Direct Violet 1 (CCRIS 2413) is an agent of dye. |
Targets&IC50 | TNF-R1-TNFα binding:2.11 µM (IC50), SARS-CoV-2-S-RBD binding to ACE2:1.47 µM (IC50), SARS-CoV-S1S2 binding to ACE2:2.63 µM (IC50) |
In vitro | 1. Solution preparation 1. Solution preparation: Dissolve Direct Violet 1 in an appropriate amount of water, usually at a concentration of 0.5-2% (adjust according to the desired depth of dyeing). 2. Working solution preparation: Dissolve Direct Violet 1 in an appropriate amount of solvent (such as DMSO or water) to the desired concentration, usually 1-10 μM. 2. Textile dye application 1. Immerse the fabric in the dye solution and use conventional textile dyeing procedures, usually heating to 60-90°C, and the dyeing time is adjustable (usually 30-60 minutes). 2. During the dyeing process, pH adjustment and temperature control can be used to optimize dye adsorption. 3. Washing and fixing: 1) After dyeing, wash the fabric with water to remove excess dye. 2) A fixing agent can be used as needed to improve the durability and color stability of the dye. III. PPI Inhibition of SARS-CoV-2 Spike Protein and ACE2 Receptor 1. Mix SARS-CoV-2 spike protein and ACE2 receptor in vitro and set different concentrations of Direct Violet 1. 2. Measure the inhibitory effect of Direct Violet 1 on protein-protein interaction using surface plasmon resonance (SPR), fluorescence resonance energy transfer (FRET) or other interaction detection techniques. 3. IC50 determination: By comparing the effects of different concentrations of Direct Violet 1, calculate its IC50 value (1.47-2.63 μM) for inhibiting the interaction between SARS-CoV-2 spike protein and ACE2 receptor. 4. Application: 1) As a tool to study the interaction between SARS-CoV-2 spike protein and ACE2 receptor. 2) As a potential candidate molecule for anti-SARS-CoV-2 drugs. |
Alias | NSC-75778, NSC75778, NSC 75778, Direct Violet N, CCRIS 2413, Airedale Violet ND |
Molecular Weight | 728.66 |
Formula | C32H22N6Na2O8S2 |
Cas No. | 2586-60-9 |
Smiles | O=S(C1=CC(O)=C2C(N=NC3=CC=C(C4=CC=C(N=NC5=C(N)C=CC6=CC(S(=O)([O-])=O)=CC(O)=C56)C=C4)C=C3)=C(N)C=CC2=C1)([O-])=O.[Na+].[Na+] |
Relative Density. | 1.64g/cm3 |
Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 55 mg/mL (75.48 mM), Sonication is recommended. ![]() | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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