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Direct Violet 1

🥰Excellent
Catalog No. T20033Cas No. 2586-60-9
Alias NSC-75778, NSC75778, NSC 75778, Direct Violet N, CCRIS 2413, Airedale Violet ND

Direct Violet 1 (CCRIS 2413) is an agent of dye.

Direct Violet 1

Direct Violet 1

🥰Excellent
Catalog No. T20033Alias NSC-75778, NSC75778, NSC 75778, Direct Violet N, CCRIS 2413, Airedale Violet NDCas No. 2586-60-9
Direct Violet 1 (CCRIS 2413) is an agent of dye.
Pack SizePriceAvailabilityQuantity
2 g$30 In Stock
1 mL x 10 mM (in DMSO)$45 In Stock
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Purity:≥98%
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Product Introduction

Bioactivity
Description
Direct Violet 1 (CCRIS 2413) is an agent of dye.
Targets&IC50
TNF-R1-TNFα binding:2.11 µM (IC50), SARS-CoV-2-S-RBD binding to ACE2:1.47 µM (IC50), SARS-CoV-S1S2 binding to ACE2:2.63 µM (IC50)
In vitro
1. Solution preparation
1. Solution preparation: Dissolve Direct Violet 1 in an appropriate amount of water, usually at a concentration of 0.5-2% (adjust according to the desired depth of dyeing).
2. Working solution preparation: Dissolve Direct Violet 1 in an appropriate amount of solvent (such as DMSO or water) to the desired concentration, usually 1-10 μM.
2. Textile dye application
1. Immerse the fabric in the dye solution and use conventional textile dyeing procedures, usually heating to 60-90°C, and the dyeing time is adjustable (usually 30-60 minutes).
2. During the dyeing process, pH adjustment and temperature control can be used to optimize dye adsorption.
3. Washing and fixing:
1) After dyeing, wash the fabric with water to remove excess dye.
2) A fixing agent can be used as needed to improve the durability and color stability of the dye.
III. PPI Inhibition of SARS-CoV-2 Spike Protein and ACE2 Receptor
1. Mix SARS-CoV-2 spike protein and ACE2 receptor in vitro and set different concentrations of Direct Violet 1.
2. Measure the inhibitory effect of Direct Violet 1 on protein-protein interaction using surface plasmon resonance (SPR), fluorescence resonance energy transfer (FRET) or other interaction detection techniques.
3. IC50 determination: By comparing the effects of different concentrations of Direct Violet 1, calculate its IC50 value (1.47-2.63 μM) for inhibiting the interaction between SARS-CoV-2 spike protein and ACE2 receptor.
4. Application:
1) As a tool to study the interaction between SARS-CoV-2 spike protein and ACE2 receptor.
2) As a potential candidate molecule for anti-SARS-CoV-2 drugs.
AliasNSC-75778, NSC75778, NSC 75778, Direct Violet N, CCRIS 2413, Airedale Violet ND
Chemical Properties
Molecular Weight728.66
FormulaC32H22N6Na2O8S2
Cas No.2586-60-9
SmilesO=S(C1=CC(O)=C2C(N=NC3=CC=C(C4=CC=C(N=NC5=C(N)C=CC6=CC(S(=O)([O-])=O)=CC(O)=C56)C=C4)C=C3)=C(N)C=CC2=C1)([O-])=O.[Na+].[Na+]
Relative Density.1.64g/cm3
Storage & Solubility Information
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 55 mg/mL (75.48 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.3724 mL6.8619 mL13.7238 mL68.6191 mL
5 mM0.2745 mL1.3724 mL2.7448 mL13.7238 mL
10 mM0.1372 mL0.6862 mL1.3724 mL6.8619 mL
20 mM0.0686 mL0.3431 mL0.6862 mL3.4310 mL
50 mM0.0274 mL0.1372 mL0.2745 mL1.3724 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
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2 Enter the in vivo formulation:
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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