TRAIL/TNFSF10 Protein, Rhesus, Recombinant

Name: TRAIL/TNFSF10 Protein, Rhesus, Recombinant
Brand: TargetMol
SKU: TMPY-02944
Rating: 4.5 (1 reviews)

(Synonyms: tumor necrosis factor (ligand) superfamily, member 10) Copy Product Info

Synonyms: tumor necrosis factor (ligand) superfamily, member 10

Catalog No. TMPY-02944 Copy Product Info

TRAIL/TNFSF10 Protein, Rhesus, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 19.6 kDa and the accession number is F6S9W7.

Pack Size	Price	USA Stock	Global Stock
5 µg	$63	7-10 days	7-10 days
10 µg	$98	7-10 days	7-10 days
20 µg	$163	7-10 days	7-10 days
50 µg	$323	7-10 days	7-10 days
100 µg	$625	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Measured by its binding ability in a functional ELISA. Immobilized Rhesus TRAIL/TNFSF10 at 2 μg/ml (100 μl/well) can bind Rhesus DcR2/TRAIL R4 hFc, the EC50 of Rhesus DcR2/TRAIL R4 hFc is 3.5-18 ng/mL.
Description	TRAIL/TNFSF10 Protein, Rhesus, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 19.6 kDa and the accession number is F6S9W7.
Species	Rhesus
Expression System	E. coli
Tag	Tag Free
Accession Number	F6S9W7
Construction	A DNA sequence encoding the rhesus TNFSF10 (NP_001252963.1) (Val114-Gly281) was expressed and purified with an initial Met. Predicted N terminal: Met
Protein Purity	> 95 % as determined by SDS-PAGE
Endotoxin	Please contact us for more information.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Synonyms	tumor necrosis factor (ligand) superfamily, member 10
Research Background	Tumor necrosis factor ligand superfamily member 10 (TNFSF10), also known as TNF-related apoptosis-inducing ligand (TRAIL), Apo-2 ligand, and CD253, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. TNFSF10 / Apo-2L / CD253 functions as a ligand that induces the process of cell death called apoptosis. TNFSF10 / TRAIL shows homology to other members of the tumor necrosis factor superfamily. As one member of the cluster of differentiation system, TNFSF10 / CD253 is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion TNFSF10 / Apo-2L / CD253 / TRAIL binds to several members of TNF receptor superfamily including TNFRSF10A / TRAILR1, TNFRSF10B / TRAILR2, TNFRSF10C / TRAILR3, TNFRSF10D / TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of TNFSF10 / TRAIL may be modulated by binding to the decoy receptors TNFRSF10C / TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8 / JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

Chemical Properties

Molecular Weight

19.6 kDa (predicted)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.