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Adaphostin

Name: Adaphostin
Brand: TargetMol
SKU: T22553
Price: 64 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22553Cas No. 241127-58-2

Alias NSC 680410, 1-Adamantyl 4-((2,5-Dihydroxybenzyl)Amino)Benzoate

Adaphostin (NSC-680410) is a p210Bcr/Abl tyrosine kinase inhibitor with IC50 of 14 μM.

Adaphostin

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Purity: 98.29%

Catalog No. T22553Alias NSC 680410, 1-Adamantyl 4-((2,5-Dihydroxybenzyl)Amino)BenzoateCas No. 241127-58-2

Adaphostin (NSC-680410) is a p210Bcr/Abl tyrosine kinase inhibitor with IC50 of 14 μM.

Pack Size	Price	Availability
5 mg	$64	In Stock
10 mg	$97	In Stock
25 mg	$198	In Stock
50 mg	$328	In Stock
100 mg	$493	In Stock
500 mg	$1,070	In Stock

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Batch Information

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Purity:98.29%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Adaphostin (NSC-680410) is a p210Bcr/Abl tyrosine kinase inhibitor with IC50 of 14 μM.
Targets&IC50	p210 (BCR-ABL):14 μM
In vitro	It also induces apoptosis in T-lymphoblastic human leukemia cell lines (IC50 values range from 16.8 to 216.3 nM) in vitro.
In vivo	Adaphostin can damage both myeloid and lymphoid leukemia cells[2].
Synonyms	NSC 680410, 1-Adamantyl 4-((2,5-Dihydroxybenzyl)Amino)Benzoate

Chemical Properties

Molecular Weight	393.48
Formula	C₂₄H₂₇NO₄
Cas No.	241127-58-2
Smiles	Oc1ccc(O)c(CNc2ccc(cc2)C(=O)OC23CC4CC(CC(C4)C2)C3)c1
Relative Density.	1.33g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: < 40 mg/mL (101.66 mM), Sonication is recommended.

DMSO: 55 mg/mL (139.78 mM), Sonication is recommended.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5414 mL	12.7071 mL	25.4143 mL	127.0713 mL
5 mM	0.5083 mL	2.5414 mL	5.0829 mL	25.4143 mL
10 mM	0.2541 mL	1.2707 mL	2.5414 mL	12.7071 mL
20 mM	0.1271 mL	0.6354 mL	1.2707 mL	6.3536 mL
50 mM	0.0508 mL	0.2541 mL	0.5083 mL	2.5414 mL
100 mM	0.0254 mL	0.1271 mL	0.2541 mL	1.2707 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc