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Roemerine

🥰Excellent
Catalog No. TN2160Cas No. 548-08-3
Alias (-)-Roemerine

Roemerine ((-)-Roemerine) is a porphyrin alkaloid from Senegalese lychee with antifungal and anticancer activity that prevents berberine efflux through inhibition of Bmr. Roemerine increases cell membrane permeability in a concentration-dependent manner and has been used in studies of fungal infections and prostate cancer.

Roemerine

Roemerine

🥰Excellent
Purity: 98%
Catalog No. TN2160Alias (-)-RoemerineCas No. 548-08-3
Roemerine ((-)-Roemerine) is a porphyrin alkaloid from Senegalese lychee with antifungal and anticancer activity that prevents berberine efflux through inhibition of Bmr. Roemerine increases cell membrane permeability in a concentration-dependent manner and has been used in studies of fungal infections and prostate cancer.
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1 mg$98In Stock
5 mg$313In Stock
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Purity:98%
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Product Introduction

Bioactivity
Description
Roemerine ((-)-Roemerine) is a porphyrin alkaloid from Senegalese lychee with antifungal and anticancer activity that prevents berberine efflux through inhibition of Bmr. Roemerine increases cell membrane permeability in a concentration-dependent manner and has been used in studies of fungal infections and prostate cancer.
In vitro
Roemerine exhibited bactericidal effects against all tested S. aureus strains (including both methicillin-resistant and methicillin-susceptible strains), with minimum inhibitory concentrations (MICs) ranging from 32 μg/mL to 64 μg/mL[2].
Synonyms(-)-Roemerine
Chemical Properties
Molecular Weight279.33
FormulaC18H17NO2
Cas No.548-08-3
Smiles[H][C@]12Cc3ccccc3-c3c4OCOc4cc(CCN1C)c23
Relative Density.1.269 g/cm3 at 20℃
Storage & Solubility Information
Storagekeep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (286.40 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (11.81 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.5800 mL17.9000 mL35.7999 mL178.9997 mL
5 mM0.7160 mL3.5800 mL7.1600 mL35.7999 mL
10 mM0.3580 mL1.7900 mL3.5800 mL17.9000 mL
20 mM0.1790 mL0.8950 mL1.7900 mL8.9500 mL
50 mM0.0716 mL0.3580 mL0.7160 mL3.5800 mL
100 mM0.0358 mL0.1790 mL0.3580 mL1.7900 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Xanthine oxidaseRoemerineAntifectionAntibiotic
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