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Exatecan-amide-bicyclo[1.1.1]pentan-1-ylmethanol

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Catalog No. T87725Cas No. 2891774-71-1

Exatecan-amide-bicyclo[1.1.1]pentan-1-ylmethanol (compound 45), a camptothecin derivative, demonstrates potent inhibitory effects on cell proliferation, exhibiting an IC 50 of 2.92 ng/mL against MDA-MB-468 cells. It is primarily utilized in cancer research [1].

Exatecan-amide-bicyclo[1.1.1]pentan-1-ylmethanol

Exatecan-amide-bicyclo[1.1.1]pentan-1-ylmethanol

😃Good
Catalog No. T87725Cas No. 2891774-71-1
Exatecan-amide-bicyclo[1.1.1]pentan-1-ylmethanol (compound 45), a camptothecin derivative, demonstrates potent inhibitory effects on cell proliferation, exhibiting an IC 50 of 2.92 ng/mL against MDA-MB-468 cells. It is primarily utilized in cancer research [1].
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$1,7204-6 weeks4-6 weeks
50 mg$2,3804-6 weeks4-6 weeks
100 mg$2,9004-6 weeks4-6 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Exatecan-amide-bicyclo[1.1.1]pentan-1-ylmethanol (compound 45), a camptothecin derivative, demonstrates potent inhibitory effects on cell proliferation, exhibiting an IC 50 of 2.92 ng/mL against MDA-MB-468 cells. It is primarily utilized in cancer research [1].
In vitro
Exatecan-amide-bicyclo[1.1.1]pentan-1-ylmethanol (compound 45) has an IC 50 value of 2.92 ng/mL in inhibiting the proliferation of MDA‑MB‑468 cells [1].
Chemical Properties
Molecular Weight559.58
FormulaC31H30FN3O6
Cas No.2891774-71-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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Keywords

ADCCytotoxinADC Cytotoxin
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