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ARB-272572

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Catalog No. T39914Cas No. 2368182-63-0

Alias ARB272572, ARB 272572

ARB-272572 is a potent inhibitor of programmed cell death ligand 1 (PD-L1) signaling that induces PD-L1 homodimer interactions and produces immunostimulatory activity in human primary cells.

ARB-272572

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Purity: 98.07%

Catalog No. T39914Alias ARB272572, ARB 272572Cas No. 2368182-63-0

ARB-272572 is a potent inhibitor of programmed cell death ligand 1 (PD-L1) signaling that induces PD-L1 homodimer interactions and produces immunostimulatory activity in human primary cells.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$132	In Stock	In Stock
5 mg	$328	In Stock	In Stock
10 mg	$473	In Stock	In Stock
25 mg	$792	In Stock	In Stock
50 mg	$1,150	In Stock	In Stock
100 mg	$1,650	-	In Stock
200 mg	$2,220	-	In Stock
1 mL x 10 mM (in DMSO)	$392	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.07%

Appearance:Solid

Color:White to Green

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	ARB-272572 is a potent inhibitor of programmed cell death ligand 1 (PD-L1) signaling that induces PD-L1 homodimer interactions and produces immunostimulatory activity in human primary cells.
Targets&IC50	PD-1/PD-L1:400 pM
In vitro	METHODS: Small molecules were screened in a cell-free in vitro homogeneous time-resolved fluorescence (HTRF) assay using αPD-L1 (MIH1) and αPD-1 (nivolumab) antibodies as positive controls. RESULTS: ARB-272572 inhibited PD-1/PD-L1 with an IC50 value of 400 pM.[1]
In vivo	"METHODS: PD-1/PD-L1 humanized mice implanted with MC38 cells expressing humanized PD-L1 and treated with ARB-272572 (10 mg/kg orally, 7 times daily, days 0-6) or αPD-L1 (10 mg/kg intraperitoneally, 3 times per week, days 0-16). Statistically significant tumor growth inhibition was observed with αPD-L1 antibody or Compound A treatment. RESULTS:ARB-272572 treatment resulted in a 60.4% reduction in mean tumor volume in 60.4% of mice after only 7 days. [1]"
Synonyms	ARB272572, ARB 272572

Chemical Properties

Molecular Weight	568.67
Formula	C₃₂H₃₆N₆O₄
Cas No.	2368182-63-0
Smiles	O=C(NC1=CC=CC(C=2C=CC=C(NC(=O)C3=NC=C(C=C3)CNCCO)C2C)=C1C)C4=NC=C(C=C4)CNCCO

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (263.77 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (5.8 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7585 mL	8.7924 mL	17.5849 mL	87.9245 mL
5 mM	0.3517 mL	1.7585 mL	3.5170 mL	17.5849 mL
10 mM	0.1758 mL	0.8792 mL	1.7585 mL	8.7924 mL
20 mM	0.0879 mL	0.4396 mL	0.8792 mL	4.3962 mL
50 mM	0.0352 mL	0.1758 mL	0.3517 mL	1.7585 mL
100 mM	0.0176 mL	0.0879 mL	0.1758 mL	0.8792 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc