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ARB-272572

Name: ARB-272572
Brand: TargetMol
SKU: T39914
Price: 139 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T39914Cas No. 2368182-63-0

Alias ARB272572, ARB 272572

ARB-272572 is a potent inhibitor of programmed cell death ligand 1 (PD-L1) signaling that induces PD-L1 homodimer interactions and produces immunostimulatory activity in human primary cells.

ARB-272572

🥰Excellent

Purity: 98.07%

Catalog No. T39914Alias ARB272572, ARB 272572Cas No. 2368182-63-0

ARB-272572 is a potent inhibitor of programmed cell death ligand 1 (PD-L1) signaling that induces PD-L1 homodimer interactions and produces immunostimulatory activity in human primary cells.

Pack Size	Price	Availability
1 mg	$139	In Stock
5 mg	$328	In Stock
10 mg	$496	In Stock
25 mg	$828	In Stock
50 mg	$1,190	In Stock
100 mg	$1,650	In Stock
200 mg	$2,220	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:98.07%

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COA HNMR HPLC

Product Introduction

Bioactivity

Description	ARB-272572 is a potent inhibitor of programmed cell death ligand 1 (PD-L1) signaling that induces PD-L1 homodimer interactions and produces immunostimulatory activity in human primary cells.
Targets&IC50	PD-1/PD-L1:400 pM
In vitro	METHODS: Small molecules were screened in a cell-free in vitro homogeneous time-resolved fluorescence (HTRF) assay using αPD-L1 (MIH1) and αPD-1 (nivolumab) antibodies as positive controls. RESULTS: ARB-272572 inhibited PD-1/PD-L1 with an IC50 value of 400 pM.[1]
In vivo	"METHODS: PD-1/PD-L1 humanized mice implanted with MC38 cells expressing humanized PD-L1 and treated with ARB-272572 (10 mg/kg orally, 7 times daily, days 0-6) or αPD-L1 (10 mg/kg intraperitoneally, 3 times per week, days 0-16). Statistically significant tumor growth inhibition was observed with αPD-L1 antibody or Compound A treatment. RESULTS:ARB-272572 treatment resulted in a 60.4% reduction in mean tumor volume in 60.4% of mice after only 7 days. [1]"
Synonyms	ARB272572, ARB 272572

Chemical Properties

Molecular Weight	568.67
Formula	C₃₂H₃₆N₆O₄
Cas No.	2368182-63-0
Smiles	O=C(NC1=CC=CC(C=2C=CC=C(NC(=O)C3=NC=C(C=C3)CNCCO)C2C)=C1C)C4=NC=C(C=C4)CNCCO
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (175.85 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7585 mL	8.7924 mL	17.5849 mL	87.9245 mL
5 mM	0.3517 mL	1.7585 mL	3.5170 mL	17.5849 mL
10 mM	0.1758 mL	0.8792 mL	1.7585 mL	8.7924 mL
20 mM	0.0879 mL	0.4396 mL	0.8792 mL	4.3962 mL
50 mM	0.0352 mL	0.1758 mL	0.3517 mL	1.7585 mL
100 mM	0.0176 mL	0.0879 mL	0.1758 mL	0.8792 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc