Thrombomodulin Protein, Human, Recombinant (His)

Name: Thrombomodulin Protein, Human, Recombinant (His)
Brand: TargetMol
SKU: TMPY-05829
Rating: 4.5 (1 reviews)

(Synonyms: TM, thrombomodulin, THRM, THPH12, CD141, BDCA3, AHUS6) Copy Product Info

Synonyms: TM, thrombomodulin, THRM, THPH12, CD141, BDCA3, AHUS6

Catalog No. TMPY-05829 Copy Product Info

Thrombomodulin Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 53.54 kDa and the accession number is P07204.

Pack Size	Price	USA Stock	Global Stock
5 µg	$93	7-10 days	7-10 days
10 µg	$152	7-10 days	7-10 days
20 µg	$248	7-10 days	7-10 days
50 µg	$577	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	Thrombomodulin Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 53.54 kDa and the accession number is P07204.
Species	Human
Expression System	HEK293 Cells
Tag	C-His
Accession Number	P07204
Construction	A DNA sequence encoding the human THBD (NP_000352.1) (Met1-Ser515) was expressed with a polyhistidine tag at the C-terminus. Predicted N terminal: Ala 19
Protein Purity	> 90 % as determined by SDS-PAGE.
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Synonyms	TM, thrombomodulin, THRM, THPH12, CD141, BDCA3, AHUS6
Research Background	Thrombomodulin, also known as THBD (CD141), is an integral membrane protein that reduces blood coagulation by converting thrombin to an anticoagulant enzyme from a procoagulant enzyme. Thrombomodulin is expressed on the surface of endothelial cells and serves as a cofactor for thrombin. It is also expressed on human mesothelial cell, monocyte and a dendritic cell subset. Thrombomodulin functions as a cofactor in the thrombin-induced activation of protein C in the anticoagulant pathway by forming a 1:1 stoichiometric complex with thrombin. Thrombomodulin also regulates C3b inactivation by factor I. Mutations in the thrombomodulin gene have also been reported to be associated with atypical hemolytic-uremic syndrome.

Chemical Properties

Molecular Weight

53.54 kDa (predicted)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.