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SB 242235

Name: SB 242235
Brand: TargetMol
SKU: T4078
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4078Cas No. 193746-75-7

Alias SB-242235, SB242235

SB 242235 is a potent and selective p38 MAP kinase inhibitor that may be an effective therapy for cytokine-mediated diseases.

SB 242235

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Purity: 99.68%

Catalog No. T4078Alias SB-242235, SB242235Cas No. 193746-75-7

SB 242235 is a potent and selective p38 MAP kinase inhibitor that may be an effective therapy for cytokine-mediated diseases.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$40	In Stock	In Stock
5 mg	$67	In Stock	In Stock
10 mg	$118	In Stock	In Stock
25 mg	$249	In Stock	In Stock
50 mg	$378	In Stock	In Stock
100 mg	$568	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$75	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.68%

Color:White to Yellow

Resource Download

COA HNMR HPLC

Product Introduction

SB 242235 AI Summary

SB 242235 exhibits significant bioactivities, particularly strong inhibition against Mitogen-activated protein kinase p38 alpha, with IC50 values ranging from 19.0 nM to 40.0 nM. This compound also moderately inhibits TNF alpha synthesis in both murine models, with an ED50 of 2.6 mg.kg-1, and LPS-stimulated TNFalpha release in human PBMC, with an IC50 of 170.0 nM. Furthermore, it has an inhibitory effect on PKC-beta2 kinase with an IC50 of 17.0 nM and weak or no significant inhibition against other kinases such as ERK2, JNK1, and EGFR. In vivo, SB 242235 is effective in reducing rat paw-swelling, bone erosion, and cartilage destruction, with TMED50 values of 5.0 mg/kg and 7.0 mg/kg for 14 days of oral dosing. The compound shows systemic exposure with significant AUC values in humans, dogs, and monkeys but lower exposure in rats. Additionally, it exhibits moderate efficacy in the inhibition of SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells, as well as in SARS-CoV-2 3CL-Pro protease activity. However, it demonstrates minimal activity against human HDAC6 in enzymatic assays. Lastly, SB 242235 shows potential in inhibiting the proliferation of Plasmodium falciparum, with potency values spanning 5951.8 nM to 21117.7 nM across different assays, and exhibits weak inhibition activity against a variety of other kinases. These findings indicate that SB 242235 has a diverse profile of bioactivities with particular potential in inflammatory and infectious disease contexts..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	SB 242235 is a potent and selective p38 MAP kinase inhibitor that may be an effective therapy for cytokine-mediated diseases.
Targets&IC50	p38 MAPk:1.0 μM
Synonyms	SB-242235, SB242235

Chemical Properties

Molecular Weight	353.39
Formula	C₁₉H₂₀FN₅O
Cas No.	193746-75-7
Smiles	COc1nccc(n1)-c1c(ncn1C1CCNCC1)-c1ccc(F)cc1
Relative Density.	1.34 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (169.78 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.66 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8297 mL	14.1487 mL	28.2973 mL	141.4867 mL
5 mM	0.5659 mL	2.8297 mL	5.6595 mL	28.2973 mL
10 mM	0.2830 mL	1.4149 mL	2.8297 mL	14.1487 mL
20 mM	0.1415 mL	0.7074 mL	1.4149 mL	7.0743 mL
50 mM	0.0566 mL	0.2830 mL	0.5659 mL	2.8297 mL
100 mM	0.0283 mL	0.1415 mL	0.2830 mL	1.4149 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc